Chemo-enzymatic synthesis of both enantiomers of rugulactone

被引：18

作者：

Reddipalli, Gowrisankar ^{[1
]}

Venkataiah, Mallam ^{[1
]}

Fadnavis, Nitin W. ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Biotransformat Lab, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 03期

关键词：

OLEFIN-METATHESIS; ALDEHYDES;

D O I：

10.1016/j.tetasy.2010.01.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of both the (R)- and (S)-enantiomers of the natural product rugulactone has been achieved. Candida rugosa lipase hydrolyzes the butyrate ester of the protected 3-hydroxy homoallylic alcohol with very high enantioselectivity (E = 244) and provides the key intermediates with high enantiomeric purity (ee 98-99%) and excellent yields. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：320 / 324

页数：5

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