Ginger extracts influence the expression of IL-27 and IL-33 in the central nervous system in experimental autoimmune encephalomyelitis and ameliorates the clinical symptoms of disease

被引：38

作者：

Jafarzadeh, A. ^{[1
,2
,3
]}

Mohammadi-Kordkhayli, M. ^{[2
]}

Ahangar-Parvin, R. ^{[3
]}

Azizi, V. ^{[3
]}

Khoramdel-Azad, H. ^{[3
]}

Shamsizadeh, A. ^{[4
]}

Ayoobi, A. ^{[4
]}

Nemati, M. ^{[2
]}

Hassan, Z. M. ^{[5
]}

Moazeni, S. M. ^{[5
]}

Khaksari, M. ^{[1
,6
]}

机构：

[1] Kerman Univ Med Sci, Neurosci Res Ctr, Dept Neurol, Kerman, Iran

[2] Kerman Univ Med Sci, Sch Med, Dept Immunol, Kerman, Iran

[3] Rafsanjan Univ Med Sci, Sch Med, Dept Immunol, Rafsanjan, Iran

[4] Rafsanjan Univ Med Sci, Sch Med, Dept Physiol, Rafsanjan, Iran

[5] Tarbiat Modares Univ, Sch Med, Dept Immunol, Tehran, Iran

[6] Kerman Univ Med Sci, Sch Med, Dept Physiol, Kerman, Iran

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 276卷 / 1-2期

关键词：

Experimental autoimmune encephalomyelitis; Ginger; IL-27; IL-33; Clinical symptoms; T-CELLS; IFN-GAMMA; MULTIPLE-SCLEROSIS; IMMUNE-RESPONSES; THERAPEUTIC-EFFICACY; CYTOKINE; INFLAMMATION; 6-SHOGAOL; CNS; INTERLEUKIN-33;

D O I：

10.1016/j.jneuroim.2014.08.614

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunomodulatory effects of the IL-27 and IL-33 and the anti-inflammatory effects of ginger have been reported in some studies. The aim was to evaluate the effects of the ginger extract on the expression of IL-27 and IL-33 in a model of experimental autoimmune encephalomyelitis (EAE). In PBS-treated EAE mice the expression of IL-27 P28 was significantly lower whereas the expression of IL-33 was significantly higher than unimmunized control mice. In 200 and 300 mg/kg ginger-treated EAE groups the expression of IL-27 P28 and IL-27 EBI3 was significantly higher whereas the expression of IL-33 was significantly lower than PBS-treated EAE mice. The EAE clinical symptoms and the pathological scores were significantly lower in ginger-treated EAE groups. These results showed that the ginger extract modulates the expression of the IL-27 and IL-33 in the spinal cord of EAE mice and ameliorates the clinical symptoms of disease. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：80 / 88

页数：9

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