Application of the Bethesda System for Reporting Thyroid Cytopathology in the Pediatric Population A Multicenter Study in Asian Countries

被引：0

作者：

Vuong, Huy Gia ^{[1
,2
]}

Suzuki, Ayana ^{[3
]}

Na, Hee Young ^{[4
]}

Van Tuyen, Pham ^{[5
]}

Khuy, Doan Minh ^{[5
]}

Nguyen, Hiep Canh ^{[5
]}

Jitpasutham, Tikamporn ^{[6
]}

Abelardo, Agustina ^{[7
,8
]}

Amano, Takashi ^{[9
]}

Park, So Yeon ^{[4
]}

Jung, Chan Kwon ^{[10
]}

Hirokawa, Mitsuyoshi ^{[3
]}

Katoh, Ryohei ^{[9
]}

Kakudo, Kennichi ^{[11
,12
]}

Bychkov, Andrey ^{[13
,14
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA

[2] Univ Oklahoma, Hlth Sci Ctr, Stephenson Canc Ctr, Oklahoma City, OK USA

[3] Kuma Hosp, Dept Diagnost Pathol & Cytol, Kobe, Hyogo, Japan

[4] Seoul Natl Univ, Bundang Hosp, Dept Pathol, Coll Med, Seongnam, South Korea

[5] Bach Mai Hosp, Ctr Pathol & Cytopathol, Hanoi, Vietnam

[6] Chulalongkorn Univ, Fac Med, Dept Pathol, Bangkok, Thailand

[7] Univ Philippines Manila, Dept Pathol, Coll Med, Manila, Philippines

[8] Philippine Gen Hosp, Dept Labs, Med Ctr, Manila, Philippines

[9] Ito Hosp, Dept Pathol, Tokyo, Japan

[10] Catholic Univ Korea, Dept Hosp Pathol, Coll Med, Seoul, South Korea

[11] Izumi City Gen Hosp, Dept Pathol, Osaka, Japan

[12] Izumi City Gen Hosp, Thyroid Dis Ctr, Osaka, Japan

[13] Kameda Med Ctr, Dept Pathol, Kamogawa, Japan

[14] Nagasaki Univ, Dept Pathol, Grad Sch Biomed Sci, Nagasaki, Japan

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2021年 / 155卷 / 05期

关键词：

The Bethesda System; Fine-needle aspiration; Thyroid; Thyroid nodules; Thyroid cancer; Risk of malignancy; Resection rate; Pediatric; Children; FINE-NEEDLE-ASPIRATION; FOLLICULAR VARIANT; NUCLEAR FEATURES; BRAF V600E; FOLLOW-UP; CARCINOMA; NODULES; CHILDREN; CYTOLOGY; CANCER;

D O I：

10.1093/AJCP/AQAA182

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: We aimed to provide the Asian experience with the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) in pediatric thyroid nodules. Methods: Consecutive thyroid fine-needle aspirates (patient age, <= 18 years) were retrospectively collected from 7 tertiary centers in 5 Asian countries. Results: Of 194,364 thyroid aspirates, 0.6% were pediatric cases (mean age, 15.0 years). Among 827 nodules with accessible follow-up, the resection rate and risk of malignancy (ROM) were 36.3% and 59.0%, respectively. Malignant nodules (n = 179) accounted for 59. 7 % of resected nodules and 21.6% of all thyroid nodules with available follow-up. Compared with the published adult series, pediatric nodules had a higher resection rate and ROM, particularly in the indeterminate categories. Conclusions: Our study demonstrates that Asian pediatric thyroid nodules had higher ROM than those from adults. The prototypic outputs of TBSRTC may need to be adjusted in the pediatric population.

引用

页码：680 / 689

页数：10

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