An antibacterial platform based on capacitive carbon-doped TiO2 nanotubes after direct or alternating current charging

被引：199

作者：

Wang, Guomin ^{[1
,2
]}

Feng, Hongqing ^{[3
,4
]}

Hu, Liangsheng ^{[5
,6
]}

Jin, Weihong ^{[1
,2
]}

Hao, Qi ^{[1
,2
]}

Gao, Ang ^{[1
,2
,7
]}

Peng, Xiang ^{[1
,2
]}

Li, Wan ^{[1
,2
]}

Wong, Kwok-Yin ^{[5
,6
]}

Wang, Huaiyu ^{[1
,2
,7
]}

Li, Zhou ^{[3
,4
]}

Chu, Paul K. ^{[1
,2
]}

机构：

[1] City Univ Hong Kong, Dept Phys, Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[2] City Univ Hong Kong, Dept Mat Sci & Engn, Tat Chee Ave, Kowloon, Hong Kong, Peoples R China

[3] Chinese Acad Sci, CAS Ctr Excellence Nanosci, Beijing Key Lab Micronano Energy & Sensor, Beijing Inst Nanoenergy & Nanosyst, Beijing 100083, Peoples R China

[4] Univ Chinese Acad Sci, Sch Nanosci & Technol, Beijing 100049, Peoples R China

[5] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China

[6] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China

[7] Chinese Acad Sci, Res Ctr Biomed Mat & Interfaces, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

ELECTRON-TRANSFER; ANTIMICROBIAL ACTIVITY; IN-VITRO; SILVER; NANOPARTICLES; BACTERIA; SURFACES; STORAGE; ENERGY; LIGHT;

D O I：

10.1038/s41467-018-04317-2

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Electrical interactions between bacteria and the environment are delicate and essential. In this study, an external electrical current is applied to capacitive titania nanotubes doped with carbon (TNT-C) to evaluate the effects on bacteria killing and the underlying mechanism is investigated. When TNT-C is charged, post-charging antibacterial effects proportional to the capacitance are observed. This capacitance-based antibacterial system works well with both direct and alternating current (DC, AC) and the higher discharging capacity in the positive DC (DC+) group leads to better antibacterial performance. Extracellular electron transfer observed during early contact contributes to the surface-dependent post-charging antibacterial process. Physiologically, the electrical interaction deforms the bacteria morphology and elevates the intracellular reactive oxygen species level without impairing the growth of osteoblasts. Our finding spurs the design of light-independent antibacterial materials and provides insights into the use of electricity to modify biomaterials to complement other bacteria killing measures such as light irradiation.

引用

页数：12

共 68 条

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