Conicaquinones A and B, two novel cytotoxic terpene quinones from the Mediterranean ascidian Aplidium conicum

被引：28

作者：

Aiello, A

Fattorusso, E

Luciano, P

Menna, M

Esposito, G

Iuvone, T

Pala, D

机构：

[1] Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Dipartimento Farmacol Sperimentale, I-80131 Naples, Italy

[3] Battelle Mem Inst, Geneva, Switzerland

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 2003卷 / 05期

关键词：

ascidians; natural products; quinones; terpenoids; thiazinoquinones;

D O I：

10.1002/ejoc.200390136

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new unique cytotoxic metabolites, conicaquitiones A (1) and B (2), each possessing a 1, 1-dioxo-1,4-thiazine ring, were isolated from the Mediterranean ascidian Aplidium conicum. Their structures were established by an extensive spectro-scopic analysis. Compounds 1 and 2 exhibited a strong cytotoxicity in vitro against rat glioma cells. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

引用

页码：898 / 900

页数：3

共 16 条

[1] PROTEIN-TYROSINE KINASE INHIBITORY PROPERTIES OF PLANAR POLYCYCLICS OBTAINED FROM THE MARINE SPONGE XESTOSPONGIA CF CARBONARIA AND FROM TOTAL SYNTHESIS [J].