Beyond genotype: serotonin transporter epigenetic modification predicts human brain function

被引：95

作者：

Nikolova, Yuliya S. ^{[1
,2
]}

Koenen, Karestan C. ^{[3
]}

Galea, Sandro ^{[3
]}

Wang, Chiou-Miin ^{[4
]}

Seney, Marianne L. ^{[5
]}

Sibille, Etienne ^{[5
]}

Williamson, Douglas E. ^{[6
]}

Hariri, Ahmad R. ^{[1
,2
]}

机构：

[1] Duke Univ, Neurogenet Lab, Dept Psychol & Neurosci, Durham, NC 27708 USA

[2] Duke Univ, Inst Genome Sci & Policy, Durham, NC USA

[3] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA

[5] Univ Pittsburgh, Ctr Neurosci, Dept Psychiat, Pittsburgh, PA 15260 USA

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 09期

关键词：

AMYGDALA REACTIVITY;

D O I：

10.1038/nn.3778

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.

引用

页码：1153 / 1155

页数：3

共 50 条

[31] THE SEROTONIN AGONIST M-CHLOROPHENYLPIPERAZINE (MCPP) BINDS TO SEROTONIN TRANSPORTER SITES IN HUMAN BRAIN
BAUMANN, MH
MASH, DC
STALEY, JK
NEUROREPORT, 1995, 6 (16) : 2150 - 2152
[32] Coexpression of serotonin transporter and serotonin-1A receptor in human brain: a multitracer PET study
Savli, M.
Haeusler, D.
Holik, A.
Fink, M.
Hahn, A.
Mitterhauser, M.
Wadsak, W.
Kletter, K.
Kasper, S.
Lanzenberger, R.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S259 - S259
[33] ISOLATION OF A CDNA-ENCODING THE HUMAN BRAIN-SEROTONIN TRANSPORTER
LESCH, KP
WOLOZIN, BL
ESTLER, HC
MURPHY, DL
RIEDERER, P
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1993, 91 (01) : 67 - 72
[34] PRIMARY STRUCTURE OF THE HUMAN PLATELET SEROTONIN UPTAKE SITE - IDENTITY WITH THE BRAIN-SEROTONIN TRANSPORTER
LESCH, KP
WOLOZIN, BL
MURPHY, DL
RIEDERER, P
JOURNAL OF NEUROCHEMISTRY, 1993, 60 (06) : 2319 - 2322
[35] Serotonin transporter genotype by environment: Studies on alcohol use and misuse in non-human and human primates
Todkar, Aniruddha
Nilsson, Kent W.
Oreland, Lars
Hodgins, Sheilagh
Comasco, Erika
TRANSLATIONAL NEUROSCIENCE, 2013, 4 (02) : 241 - 250
[36] Age-Related Effect of Serotonin Transporter Genotype on Amygdala and Prefrontal Cortex Function in Adolescence
Wiggins, Jillian Lee
Bedoyan, Jirair K.
Carrasco, Melisa
Swartz, Johnna R.
Martin, Donna M.
Monk, Christopher S.
HUMAN BRAIN MAPPING, 2014, 35 (02) : 646 - 658
[37] Monoamine Oxidase A Genotype Predicts Human Serotonin 1A Receptor Availability In Vivo
Mickey, Brian J.
Ducci, Francesca
Hodgkinson, Colin A.
Langenecker, Scott A.
Goldman, David
Zubieta, Jon-Kar
JOURNAL OF NEUROSCIENCE, 2008, 28 (44): : 11354 - 11359
[38] Monoamine oxidase a genotype predicts human serotonin 1A receptor availability in vivo
Mickey, Brian J.
Ducci, Francesca
David, Goldman
Zubieta, Jon-Kar
BIOLOGICAL PSYCHIATRY, 2008, 63 (07) : 90S - 90S
[39] Is serotonin transporter genotype associated with epigenetic susceptibility or vulnerability? Examination of the impact of socioeconomic status risk on African American youth
Beach, Steven R. H.
Brody, Gene H.
Lei, Man Kit
Kim, Sangjin
Cui, Juan
Philibert, Robert A.
DEVELOPMENT AND PSYCHOPATHOLOGY, 2014, 26 (02) : 289 - 304
[40] Characterization of serotonin transporter function in immortalized human lymphoblastoid cell lines
Hill-Kapturczak, Nathalie
Dougherty, Donald M.
Galindo, David
Javors, Martin
FASEB JOURNAL, 2011, 25

← 1 2 3 4 5 →