Beyond genotype: serotonin transporter epigenetic modification predicts human brain function

被引：95

作者：

Nikolova, Yuliya S. ^{[1
,2
]}

Koenen, Karestan C. ^{[3
]}

Galea, Sandro ^{[3
]}

Wang, Chiou-Miin ^{[4
]}

Seney, Marianne L. ^{[5
]}

Sibille, Etienne ^{[5
]}

Williamson, Douglas E. ^{[6
]}

Hariri, Ahmad R. ^{[1
,2
]}

机构：

[1] Duke Univ, Neurogenet Lab, Dept Psychol & Neurosci, Durham, NC 27708 USA

[2] Duke Univ, Inst Genome Sci & Policy, Durham, NC USA

[3] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Mol Med, San Antonio, TX 78229 USA

[5] Univ Pittsburgh, Ctr Neurosci, Dept Psychiat, Pittsburgh, PA 15260 USA

[6] Univ Texas Hlth Sci Ctr San Antonio, Dept Psychiat, San Antonio, TX 78229 USA

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 09期

关键词：

AMYGDALA REACTIVITY;

D O I：

10.1038/nn.3778

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined epigenetic regulation in regards to behaviorally and clinically relevant human brain function. Specifically, we found that increased promoter methylation of the serotonin transporter gene predicted increased threat-related amygdala reactivity and decreased mRNA expression in postmortem amygdala tissue. These patterns were independent of functional genetic variation in the same region. Furthermore, the association with amygdala reactivity was replicated in a second cohort and was robust to both sampling methods and age.

引用

页码：1153 / 1155

页数：3

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