Hydroxytyrosol: from laboratory investigations to future clinical trials

被引:242
作者
Granados-Principal, Sergio [2 ]
Quiles, Jose L. [3 ]
Ramirez-Tortosa, Cesar L. [4 ]
Sanchez-Rovira, Pedro [5 ]
Carmen Ramirez-Tortosa, M. [1 ,2 ]
机构
[1] Univ Granada, Inst Nutr & Tecnol Alimentos Jose Mataix Verdu, Ctr Invest Biomed, E-18071 Granada, Spain
[2] Univ Granada, Dept Biochem & Mol Biol 2, E-18071 Granada, Spain
[3] Univ Granada, Dept Physiol, E-18071 Granada, Spain
[4] Complejo Hosp Ciudad Jaen, Dept Anatomopathol, Jaen, Spain
[5] Complejo Hosp Ciudad Jaen, Dept Oncol, Jaen, Spain
关键词
cardiovascular disease; cancer; hydroxytyrosol; Mediterranean diet; olive oil; VIRGIN OLIVE OIL; PERIPHERAL VASCULAR-DISEASE; LOW-DENSITY-LIPOPROTEIN; LONG-TERM ADAPTATION; PHENOLIC-COMPOUNDS; FATTY-ACIDS; SUNFLOWER OIL; OXIDATIVE STRESS; MINOR COMPONENTS; DIETARY OILS;
D O I
10.1111/j.1753-4887.2010.00278.x
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Mediterranean countries have lower rates of mortality from cardiovascular disease and cancer than Northern European or other Western countries. This has been attributed, at least in part, to the so-called Mediterranean diet, which is composed of specific local foods, including olive oil. Traditionally, many beneficial properties associated with this oil have been ascribed to its high oleic acid content. Today, it is clear that many of the beneficial effects of ingesting virgin olive oil are due to its minor compounds. This review summarizes the existing knowledge concerning the chemistry, pharmacokinetics, and toxicology of hydroxytyrosol, a minor compound of virgin olive oil, as well as this compound's importance for health. The main findings in terms of its beneficial effects in cardiovascular disease and cancer, including its properties against inflammation and platelet aggregation, are emphasized. New evidence and strategies regarding the use of hydroxytyrosol as a natural drug for the prevention and treatment of diseases with high incidences in Western countries are also presented.
引用
收藏
页码:191 / 206
页数:16
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