Antimicrobial triterpenes from Poulsenia armata Miq. Standl.

被引：24
作者：
El-Seedi, HR [1 ]
机构：
[1] Menoufia Univ, Fac Sci, El Kom, Egypt
[2] Uppsala Univ, Biomed Ctr, Div Pharmacognosy, SE-75123 Uppsala, Sweden
来源：
NATURAL PRODUCT RESEARCH | 2005年 / 19卷 / 02期
关键词：
Poulsenia arinata; Moraceae; triterpenes; antimicrobial activity; accelerating gradient; chromatography; NMR and NIS spectrometry;
D O I：
10.1080/14786410410001730724
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Crude petroleum ether extract from the bark of Poulsenia armata showed antimicrobial activity. Activity-guided fractionation led to the isolation and structure elucidation of two active new triterpene derivatives, the stearate of glut-5-en-3beta-ol (1) and 3beta,28-diacetoxyurs-12-ene (4), for the first time as naturally occurring compounds. Compound 4 has previously been synthesized. The structures were determined by 1D- and 2D-NMR spectroscopy, mass spectrometry and chemical transformations. This is the first report on the chemistry and pharmacology of the genus.
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收藏
页码：197 / 202
页数：6
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