Polihexanide: A Safe and Highly Effective Biocide

被引：99

作者：

Kaehn, K. ^{[1
]}

机构：

[1] K2 Hyg Dienstleistungen, DE-67431 Aschaffenburg, Germany

来源：

SKIN PHARMACOLOGY AND PHYSIOLOGY | 2010年 / 23卷

关键词：

Polihexanide; chemical characteristics; Biocide; Antiseptic; Wounds; POLYHEXAMETHYLENE BIGUANIDE PHMB; IN-VITRO SUSCEPTIBILITY; ESCHERICHIA-COLI; PHOSPHOLIPID-MEMBRANES; ACANTHAMOEBA-KERATITIS; BACTERIAL; WOUNDS; MODEL; CHLORHEXIDINE; DEFENSINS;

D O I：

10.1159/000318237

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Polihexanide is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. The physicochemical action on the bacterial envelope prevents or impedes the development of resistant bacterial strains. Thus, polihexanide is particularly suitable and useful in the struggle against multidrug-resistant bacteria. The ecological database is still incomplete. There is some evidence that biodegradation requires adsorption to inert surfaces and that only a small number of bacterial species are capable of utilizing polihexanide. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：7 / 16

页数：10

共 66 条

[1] The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide [J].

Allen, MJ ;

White, GF ;

Morby, AP .

MICROBIOLOGY-SGM, 2006, 152 :989-1000

[2]

Andriessen AE, 2008, WOUNDS, V20, P171

[3]

Berg A, 2008, HYG MED, V33, P189

[4] Why chronic wounds will not heal: a novel hypothesis [J].

Bjarnsholt, Thomas ;

Kirketerp-Moller, Klaus ;

Jensen, Peter Ostrup ;

Madsen, Kit G. ;

Phipps, Richard ;

Krogfelt, Karen ;

Hoiby, Niels ;

Givskov, Michael .

WOUND REPAIR AND REGENERATION, 2008, 16 (01) :2-10

[5] Sorption of poly(hexamethylenebiguanide) on cellulose: Mechanism of binding and molecular recognition [J].

Blackburn, RS ;

Harvey, A ;

Kettle, LL ;

Payne, JD ;

Russell, SJ .

LANGMUIR, 2006, 22 (13) :5636-5644

[6]

BRATT H, 1976, MAKROMOL CHEM, V177, P2591

[7]

BRECX M, 2008, J DENT RES, V87

[8] INTERACTION OF SOME POLYHEXAMETHYLENE BIGUANIDES AND MEMBRANE PHOSPHOLIPIDS IN ESCHERICHIA-COLI [J].

BROXTON, P ;

WOODCOCK, PM ;

HEATLEY, F ;

GILBERT, P .

JOURNAL OF APPLIED BACTERIOLOGY, 1984, 57 (01) :115-124

[9]

Cazzaniga A, 2002, WOUNDS, V14, P169

[10]

CHRISTIANSEN R, 1996, B ENVIRON CONTAM TOX, V36, P121

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