[NiII(3-OMe-salophene)]: A Potent Agent with Antitumor Activity

被引：44

作者：

Lee, Soo-Young ^{[2
]}

Hille, Annegret ^{[3
]}

Frias, Corazon ^{[4
]}

Kater, Benjamin ^{[2
]}

Bonitzki, Birgit ^{[2
]}

Woelfl, Stefan ^{[5
]}

Scheffler, Heike ^{[3
]}

Prokop, Aram ^{[2
,4
]}

Gust, Ronald ^{[1
,3
]}

机构：

[1] Univ Innsbruck, Dept Pharmaceut Chem, Inst Pharm, A-6020 Innsbruck, Austria

[2] Univ Med Ctr Charite, Dept Pediat Oncol Hematol, Berlin, Germany

[3] Free Univ Berlin, Inst Pharm, D-1000 Berlin, Germany

[4] Childrens Hosp City Cologne, Dept Pediat Oncol, Cologne, Germany

[5] Inst Pham & Mol Biotechnol, D-69120 Heidelberg, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 53卷 / 16期

关键词：

NICKEL(II) COMPLEXES; DEATH KNELL; APOPTOSIS; PHOSPHATIDYLSERINE; DNA;

D O I：

10.1021/jm100459k

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this study, we investigated the anticancer properties of methoxy-substituted nickel(II)(salophene) derivatives. We demonstrated that the most active complex [Ni-II(3-OMe-salophene)] is not necrotic in Burkitt-like lymphoma cells (BJAB) and human B-cell precursor cells (Nalm-6). [Ni-II(3-OMe-salophene)] inhibited proliferation and induced apoptosis in a concentration dependent manner, giving evidence for the involvement of CD95 receptor-mediated, extrinsic pathway. Furthermore, [Ni-II(3-OMe-salophene)] overcame vincristine drug resistance in BJAB and Nalm-6 cells.

引用

页码：6064 / 6070

页数：7

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