Differential cerebral reactivity to shortest and longer tones: Neuromagnetic and behavioral evidence

被引：11

作者：

Cheng, Chia-Hsiung ^{[1
,5
]}

Hsu, Wan-Yu ^{[1
,5
]}

Shih, Yang-Hsin ^{[2
,6
]}

Lin, Hsuan-Chun ^{[1
,5
]}

Liao, Kwong-Kum ^{[2
,6
]}

Wu, Zin-An ^{[2
,6
]}

Lin, Yung-Yang ^{[1
,2
,3
,4
,5
,6
]}

机构：

[1] Natl Yang Ming Univ, Inst Brain Sci, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Dept Neurol, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Physiol, Taipei 112, Taiwan

[4] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[5] Taipei Vet Gen Hosp, Neurophysiol Lab, Integrated Brain Res Lab, Taipei 112, Taiwan

[6] Taipei Vet Gen Hosp, Neurol Inst, Taipei 112, Taiwan

来源：

HEARING RESEARCH | 2010年 / 268卷 / 1-2期

关键词：

MISMATCH NEGATIVITY MMN; HUMAN AUDITORY-CORTEX; SOUND DURATION; VOWEL DURATION; LANGUAGE EXPERIENCE; NATIVE-SPEAKERS; PITCH CHANGES; HUMAN BRAIN; DISCRIMINATION; MEMORY;

D O I：

10.1016/j.heares.2010.06.009

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

Detecting a change in sound duration is important in language processing. The cerebral reactivity to a duration deviant in oddball paradigm has been reflected as a mismatch negativity (MMN). This study aimed to see cerebral responses to several duration-varying sounds presented with equal probability. Magnetoencephalographic (MEG) and behavior responses to equi-probable sounds (25-50-75-100-125 ms or 50-75-100-125-150 ms tones) were recorded in 10 healthy adult volunteers. By subtracting the average of the responses to 4 longer tones from the response to the shortest tone, a clear deflection peaking at 100-200 ms from stimulus onset was identified. This activity was called as substandard MMNm, and its amplitude tended to increase with the increment of duration deviance within a stimulation paradigm. The source of sub-standard MMNm was localized in superior temporal area, with 5-6 mm more anterior to the generator of N100m response. Behavioral tests also showed best performance in the recognition of the shortest tone than longer tones. In conclusion, the preferential response to the shortest tone in an equiprobable paradigm suggests an asymmetrical processing in the auditory cortex for duration-varying sounds. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：260 / 270

页数：11

共 56 条

[51] TONOTOPIC AUDITORY-CORTEX AND THE MAGNETOENCEPHALOGRAPHIC (MEG) EQUIVALENT OF THE MISMATCH NEGATIVITY [J].