Acute suppression of TGF-β with local, sustained release of tranilast against the formation of fibrous capsules around silicone implants

被引：43

作者：

Park, Subin ^{[1
]}

Park, Min ^{[2
]}

Kima, Byung Hwi ^{[1
]}

Lee, Ji Eun ^{[2
]}

Park, Hyo Jin ^{[3
]}

Lee, Seung Ho ^{[2
]}

Park, Chun Gwon ^{[4
]}

Kim, Myung Hun ^{[2
]}

Kim, Ryul ^{[1
]}

Kim, Eun Hee ^{[6
]}

Heo, Chan Yeong ^{[5
,6
]}

Choy, Young Bin ^{[1
,2
,4
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Biomed Engn, Seoul 110799, South Korea

[2] Seoul Natl Univ, Coll Engn, Interdisciplinary Program Bioengn, Seoul 152742, South Korea

[3] Seoul Natl Univ, Bundang Hosp, Dept Pathol, Songnam 463707, South Korea

[4] Seoul Natl Univ, Med Res Ctr, Inst Med & Biol Engn, Seoul 110799, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Plast & Reconstruct Surg, Seoul 110799, South Korea

[6] Seoul Natl Univ, Bundang Hosp, Dept Plast & Reconstruct Surg, Songnam 463707, South Korea

来源：

JOURNAL OF CONTROLLED RELEASE | 2015年 / 200卷

关键词：

Capsular contracture; Fibrosis; Macrophage; Silicone implant; TGF; Tranilast; GROWTH-FACTOR-BETA; BREAST IMPLANTS; MACROPHAGE PRODUCTION; MATRIX ACCUMULATION; COLLAGEN-SYNTHESIS; INFLAMMATION; EXPRESSION; TGF-BETA-1; DEPOSITION; RESOLUTION;

D O I：

10.1016/j.jconrel.2014.12.021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We propose the acute, local suppression of transforming growth factor beta (TGF-beta), a major profibrotic cytokine, to reduce fibrosis around silicone implants. To this end, we prepared silicone implants that were able to release tranilast, a TGF-beta inhibitor, in a sustained manner for 5 days or 15 days. We performed histologic and immuno-histochemical analyses for 12weeks after the implantation of the implants in living rats. The capsule thicknesses and collagen densities significantly decreased compared with those around the non-treated silicone implants. Notably, early suppression of TGF-beta affected the fibrogenesis that actually occurs at the late stage of wound healing. This change may be ascribed to the decrease in monocyte recruitment mediated by early TGF-beta during the acute inflammatory reaction. Thus, a significant decrease in differentiated macrophages was observed along with a decrease in the quantity of TGF-beta and fibroblasts during the subsequent inflammation stage; these changes led to a diminished fibrotic capsule formation. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：125 / 137

页数：13

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