Two-Photon Excited Fluorescence Enhancement for Ultrasensitive DNA Detection on Large-Area Gold Nanopatterns

被引:35
作者
Jung, Jin-Mi [1 ,2 ]
Yoo, Hae-Wook [1 ]
Stellacci, Francesco [2 ]
Jung, Hee-Tae [1 ]
机构
[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn BK 21, Taejon 305701, South Korea
[2] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA
关键词
PLASMON; SURFACE; FLUOROPHORES; DISTANCE;
D O I
10.1002/adma.200903745
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Ultrasensitive DNA detection using enhanced two-photon excited fluorescence: DNA detection systems formed on a highly regular gold nanopattern over a large area show enhanced sensitivity from high to ultralow concentrations (similar to 10-11 M, see figure) target molecules. The observed two-photon excited fluorescence on the gold patterned surface is enhanced over two orders of magnitude compared with the molecules on the glass surface.
引用
收藏
页码:2542 / 2546
页数:5
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