Mechanisms governing the control of mRNA translation

被引：57
作者：
Livingstone, Mark [1 ,2 ]
Atas, Evrim [3 ,4 ]
Meller, Amit [3 ,4 ]
Sonenberg, Nahum [1 ,2 ]
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ H3A 1A3, Canada
[2] McGill Univ, McGill Canc Ctr, Montreal, PQ H3A 1A3, Canada
[3] Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA
[4] Boston Univ, Dept Phys, Boston, MA 02215 USA
来源：
PHYSICAL BIOLOGY | 2010年 / 7卷 / 02期
关键词：
INITIATION-FACTOR; 4E; MAMMALIAN TARGET; MOTIF PHOSPHORYLATION; BINDING PARTNER; MTOR; RAPAMYCIN; PROTEIN; ACTIVATION; PATHWAY; CANCER;
D O I：
10.1088/1478-3975/7/2/021001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The translation of cellular mRNA to protein is a tightly controlled process often deregulated in diseases such as cancer. Furthering our understanding of mRNA structural elements and the intracellular proteins and signaling pathways that affect protein expression is crucial in the development of new therapies. In this review, we discuss the current state-of-the-art of detecting and determining the role of mRNA sequence elements in regulating the initiation of mRNA translation and the therapeutic strategies that exploit this knowledge to treat disease.
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页数：8
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