Brain Atrophy in Radiologically Isolated Syndromes

被引:50
作者
Ignacio Rojas, Juan [1 ]
Patrucco, Liliana [1 ]
Miguez, Jimena [1 ]
Besada, Cristina [2 ]
Cristiano, Edgardo [1 ]
机构
[1] Hosp Italiano Buenos Aires, Dept Neurol, Multiple Sclerosis Ctr Buenos Aires CEMBA, RA-1411 Buenos Aires, DF, Argentina
[2] Hosp Italiano Buenos Aires, Dept Neuroradiol, RA-1411 Buenos Aires, DF, Argentina
关键词
Radiologically isolated syndrome; multiple sclerosis; magnetic resonance imaging; MULTIPLE-SCLEROSIS; LESION LOAD; DISABILITY;
D O I
10.1111/jon.12182
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
INTRODUCTION The aim of this study was to compare brain atrophy in radiologically isolated syndrome (RIS), in clinically isolated syndrome (CIS), and in individuals with subjective complaints (ISC). METHODS Patients with RIS were included prospectively during June 2009 to June 2012. CIS patients and ISC were used to compare the RIS sample. An automated analysis tool, SIENAX, was used to obtain normalized total brain volume (NTBV), normalized cortical volume (NCV), and normalized white matter volume (NWMV). ANOVA test was used to analyze the data. RESULTS A total of 10 RIS patients, 43 CIS patients, and 29 ISC were included. The NTBV in RIS was 1.56 mm(3) x 10(6), 1.52 x 10(6) in CIS, and 1.64 x 10(6) in ISC (P = .12 vs. CIS and P = .003 vs. ISC); the NCV in RIS was .59 x 10(6), .55 x 10(6) in CIS, and .71 x 10(6) in ISC (P = .22 vs. CIS and P = .002 vs. ISC), and NWMV in RIS was 1.1 x 10(6), 1 in CIS and 1.12 x 10(6) in ISC (P = .66 vs. CIS and P = .12 vs. ISC). CONCLUSIONS NTBV and NCV were significantly lower in RIS compared with ISC while no differences were observed in NWMV.
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收藏
页码:68 / 71
页数:4
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