Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009

被引：378
作者：
Andersson N.
Arena M.
Auteri D.
Barmaz S.
Grignard E.
Kienzler A.
Lepper P.
Lostia A.M.
Munn S.
Parra Morte J.M.
Pellizzato F.
Tarazona J.
Terron A.
Van der Linden S.
机构：
来源：
EFSA JOURNAL | 2018年 / 16卷 / 06期
关键词：
biocidal product; plant protection product; endocrine disruptor; guidance; hazard identification; RECEPTOR-BINDING-AFFINITY; INFLATION FOLLOWING EXPOSURE; BRADFORD-HILL CONSIDERATIONS; IN-SILICO PREDICTION; FIELD ANALYSIS COMFA; LARGE DIVERSE SET; ESTROGEN-RECEPTOR; RISK-ASSESSMENT; CIRCULATING HORMONES; END-POINTS;
D O I：
10.2903/j.efsa.2018.5311
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This Guidance describes how to perform hazard identification for endocrine-disrupting properties by following the scientific criteria which are outlined in Commission Delegated Regulation (EU) 2017/2100 and Commission Regulation (EU) 2018/605 for biocidal products and plant protection products, respectively. (C) 2018 European Chemicals Agency and (C) European Food Safety Authority.
引用
收藏
页数：168
相关论文
共 208 条
[1]   Guidance on tiered risk assessment for plant protection products for aquatic organisms in edge-of-field surface waters [J].
Aagaard, Alf ;
Brock, Theo ;
Capri, Ettore ;
Duquesne, Sabine ;
Filipic, Metka ;
Hernandez-Jerez, Antonio F. ;
Hirsch-Ernst, Karen I. ;
Bennekou, Susanne Hougaard ;
Klein, Michael ;
Kuhl, Thomas ;
Laskowski, Ryszard ;
Liess, Matthias ;
Mantovani, Alberto ;
Ockleford, Colin ;
Ossendorp, Bernadette ;
Pickford, Daniel ;
Smith, Robert ;
Sousa, Paulo ;
Sundh, Ingvar ;
Tiktak, Aaldrik ;
Van der Linden, Ton .
EFSA JOURNAL, 2013, 11 (07)
[2]   Scientific Opinion on good modelling practice in the context of mechanistic effect models for risk assessment of plant protection products [J].
Aagaard, Alf ;
Brock, Theo ;
Capri, Ettore ;
Duquesne, Sabine ;
Filipic, Metka ;
Hernandez-Jerez, Antonio F. ;
Hirsch-Ernst, Karen I. ;
Bennekou, Susanne Hougaard ;
Klein, Michael ;
Kuhl, Thomas ;
Laskowski, Ryszard ;
Liess, Matthias ;
Mantovani, Alberto ;
Ockleford, Colin ;
Ossendorp, Bernadette ;
Pickford, Daniel ;
Smith, Robert ;
Sousa, Paulo ;
Sundh, Ingvar ;
Tiktak, Aaldrik ;
Van Der Linden, Ton .
EFSA JOURNAL, 2014, 12 (03)
[3]   Estrogen augments the T cell-dependent but not the T-independent immune response [J].
Adori, Monika ;
Kiss, Endre ;
Barad, Zsuzsanna ;
Barabas, Klaudia ;
Kiszely, Edda ;
Schneider, Andrea ;
Sziksz, Erna ;
Abraham, Istvan M. ;
Matko, Janos ;
Sarmay, Gabriella .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2010, 67 (10) :1661-1674
[4]   Two-step models to predict binding affinity of chemicals to the human estrogen receptor α by three-dimensional quantitative structure-activity relationships (3D-QSARs) using receptor-ligand docking simulation [J].
Akahori, Y ;
Nakai, M ;
Yakabe, Y ;
Takatsuki, A ;
Mizutani, M ;
Matsuo, M ;
Shimohigashi, Y .
SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2005, 16 (04) :323-337
[5]   The application of molecular modelling in the safety assessment of chemicals: A case study on ligand-dependent PPARγ dysregulation [J].
Al Sharif, Merilin ;
Tsakovska, Ivanka ;
Pajeva, Ilza ;
Alov, Petko ;
Fioravanzo, Elena ;
Bassan, Arianna ;
Kovarich, Simona ;
Yang, Chihae ;
Mostrag-Szlichtyng, Aleksandra ;
Vitcheva, Vessela ;
Worth, Andrew R. ;
Richarz, Andrea-N. ;
Cronin, Mark T. D. .
TOXICOLOGY, 2017, 392 :140-154
[6]   Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment [J].
Alexander, Jan ;
Benford, Diane ;
Chaudhry, Qasim ;
Hardy, Anthony ;
Jeger, Michael John ;
Luttik, Robert ;
Martin, Ambroise ;
Ossendorp, Bernadette ;
More, Simon ;
Mortensen, Alicja ;
Noerrung, Birgit ;
Perry, Joe ;
Pratt, Iona ;
Sofos, John ;
Schlatter, Josef ;
Sejrsen, Kristen .
EFSA JOURNAL, 2013, 11 (03)
[7]   The Diversity of Mechanisms Influenced by Transthyretin in Neurobiology: Development, Disease and Endocrine Disruption [J].
Alshehri, B. ;
D'Souza, D. G. ;
Lee, J. Y. ;
Petratos, S. ;
Richardson, S. J. .
JOURNAL OF NEUROENDOCRINOLOGY, 2015, 27 (05) :303-323
[8]   Effects of 17α-ethynylestradiol on EROD activity, spiggin and vitellogenin in three-spined stickleback (Gasterosteus aculeatus) [J].
Andersson, Carin ;
Katsiadaki, Ioanna ;
Lundstedt-Enkel, Katrin ;
Orberg, Jan .
AQUATIC TOXICOLOGY, 2007, 83 (01) :33-42
[9]   Scientific and Regulatory Policy Committee (SRPC) Paper: Assessment of Circulating Hormones in Nonclinical Toxicity Studies III. Female Reproductive Hormones [J].
Andersson, Hakan ;
Rehm, Sabine ;
Stanislaus, Dinesh ;
Wood, Charles E. .
TOXICOLOGIC PATHOLOGY, 2013, 41 (06) :921-934
[10]   Investigation of central versus peripheral effects of estradiol in ovariectomized mice [J].
Andersson, N ;
Islander, U ;
Egecioglu, E ;
Löf, E ;
Swanson, C ;
Movérare-Skrtic, S ;
Sjögren, K ;
Lindberg, MK ;
Carlsten, H ;
Ohlsson, C .
JOURNAL OF ENDOCRINOLOGY, 2005, 187 (02) :303-309
12345678910