Physical Activity and Survival among Men Diagnosed with Prostate Cancer

被引:115
作者
Bonn, Stephanie E. [1 ]
Sjolander, Arvid [1 ]
Lagerros, Ylva Trolle [2 ]
Wiklund, Fredrik [1 ]
Stattin, Par [3 ]
Holmberg, Erik [4 ]
Gronberg, Henrik [1 ]
Balter, Katarina [1 ]
机构
[1] Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden
[2] Karolinska Inst, Dept Med, Clin Epidemiol Unit, S-17177 Stockholm, Sweden
[3] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden
[4] Univ Gothenburg, Inst Clin Sci, Dept Oncol, Sahlgrenska Acad, Gothenburg, Sweden
关键词
RISK; EXERCISE; REGISTER; VALIDITY; OUTCOMES; THERAPY; REDUCE;
D O I
10.1158/1055-9965.EPI-14-0707
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Few studies have investigated the association between post-diagnosis physical activity and mortality among men diagnosed with prostate cancer. The aim of this study was to investigate the effect of physical activity after a prostate cancer diagnosis on both overall and prostate cancer-specific mortality in a large cohort. Methods: Data from 4,623 men diagnosed with localized prostate cancer 1997-2002 and followed-up until 2012 were analyzed. HRs with 95% confidence intervals (CI) were estimated using Cox proportional hazards models to examine the association between post-diagnosis recreational MET-h/d, time spent walking/bicycling, performing household work or exercising, and time to overall and prostate cancer-specific death. All models were adjusted for potential confounders. Results: During the follow-up, 561 deaths of any cause and 194 deaths from prostate cancer occurred. Statistically significantly lower overall mortality rates were found among men engaged in 5 recreationalMET-h/d (HR, 0.63; 95% CI, 0.52-0.77), walking/ bicycling 20 min/d (HR, 0.70; 95% CI, 0.57-0.86), performing householdwork > 1 h/d (HR, 0.71; 95% CI, 0.59-0.86), or exercising > 1 h/wk (HR, 0.74; 95% CI, 0.61-0.90), compared with less active men within each activity type. For prostate cancer-specific mortality, statistically significantly lower mortality rates were seen among men walking/bicycling >= 20 min/d (HR, 0.61; 95% CI, 0.43-0.87) or exercising 1 h/wk (HR, 0.68; 95% CI, 0.48-0.94). Conclusions: Higher levels of physical activity were associated with reduced rates of overall and prostate cancer-specific mortality. Impact: Our study further strengthens previous results indicating beneficial effects of physical activity on survival among men with prostate cancer. Cancer Epidemiol Biomarkers Prev; 24(1); 57-64. (C) 2014 AACR.
引用
收藏
页码:57 / 64
页数:8
相关论文
共 28 条
[1]   2011 Compendium of Physical Activities: A Second Update of Codes and MET Values [J].
Ainsworth, Barbara E. ;
Haskell, William L. ;
Herrmann, Stephen D. ;
Meckes, Nathanael ;
Bassett, David R., Jr. ;
Tudor-Locke, Catrine ;
Greer, Jennifer L. ;
Vezina, Jesse ;
Whitt-Glover, Melicia C. ;
Leon, Arthur S. .
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2011, 43 (08) :1575-1581
[2]   Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic Review [J].
Ballard-Barbash, Rachel ;
Friedenreich, Christine M. ;
Courneya, Kerry S. ;
Siddiqi, Sameer M. ;
McTiernan, Anne ;
Alfano, Catherine M. .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2012, 104 (11) :815-840
[3]   The completeness of the Swedish Cancer Register - a sample survey for year 1998 [J].
Barlow, Lotti ;
Westergren, Kerstin ;
Holmberg, Lars ;
Talback, Mats .
ACTA ONCOLOGICA, 2009, 48 (01) :27-33
[4]   A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer [J].
Barnard, R. James ;
Leung, Pak Shan ;
Aronson, William J. ;
Cohen, Pinchas ;
Golding, Lawrence A. .
EUROPEAN JOURNAL OF CANCER PREVENTION, 2007, 16 (05) :415-421
[5]   A low-fat diet and/or strenuous exercise alters the IGF axis in vivo and reduces prostate tumor cell growth in vitro [J].
Barnard, RJ ;
Ngo, TH ;
Leung, PS ;
Aronson, WJ ;
Golding, LA .
PROSTATE, 2003, 56 (03) :201-206
[6]  
Bergman O., 2013, Cancer i siffror 2013, V6
[7]  
COX DR, 1972, J R STAT SOC B, V34, P187
[8]   Combined Resistance and Aerobic Exercise Program Reverses Muscle Loss in Men Undergoing Androgen Suppression Therapy for Prostate Cancer Without Bone Metastases: A Randomized Controlled Trial [J].
Galvao, Daniel A. ;
Taaffe, Dennis R. ;
Spry, Nigel ;
Joseph, David ;
Newton, Robert U. .
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (02) :340-347
[9]   Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review [J].
Gardner, Jason R. ;
Livingston, Patricia M. ;
Fraser, Steve F. .
JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (04) :335-+
[10]  
JEMAL A, 2011, CA-CANCER J CLIN, V61, P69, DOI DOI 10.3322/CAAC.20107