Flavonoids as potential anti-platelet aggregation agents: from biochemistry to health promoting abilities

被引：51

作者：

Sharifi-Rad, Javad ^{[1
,2
]}

Quispe, Cristina ^{[3
]}

Shaheen, Shabnum ^{[4
]}

El Haouari, Mohammed ^{[5
,6
]}

Azzini, Elena ^{[7
]}

Butnariu, Monica ^{[8
]}

Sarac, Ioan ^{[8
]}

Pentea, Marius ^{[8
]}

Ramirez-Alarcon, Karina ^{[9
]}

Martorell, Miquel ^{[9
,10
]}

Kumar, Manoj ^{[11
]}

Docea, Anca Oana ^{[12
]}

Cruz-Martins, Natalia ^{[13
,14
,15
]}

Calina, Daniela ^{[16
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Phytochem Res Ctr, Tehran 141556153, Iran

[2] Univ Azuay, Fac Med, Cuenca, Ecuador

[3] Univ Arturo Prat, Fac Ciencias Salud, Iquique, Chile

[4] LCWU, Dept Plant Sci, Lahore, Pakistan

[5] Ctr Reg Metiers Educ & Format Reg Fes Meknes Ante, Taza Gare, Morocco

[6] Univ Sidi Mohamed Ben Abdellah, Fac Polydisciplinaire Taza, Lab Mat Subst Nat Environm & Modelisat LMSNEM, Taza Gare, Morocco

[7] Council Agr Res & Econ CREA, Ctr Res Food & Nutr, Rome, Italy

[8] Banats Univ Agr Sci & Vet Med King Michael I Roma, Timis, Romania

[9] Univ Concepcion, Fac Pharm, Dept Nutr & Dietet, Concepcion, Chile

[10] Univ Concepcion, UDT, Unidad Desarrollo Tecnol, Concepcion, Chile

[11] ICAR Cent Inst Res Cotton Technol, Chem & Biochem Proc Div, Mumbai 400019, Maharashtra, India

[12] Univ Med & Pharm Craiova, Dept Toxicol, Craiova, Romania

[13] Univ Porto, Fac Med, P-4200319 Porto, Portugal

[14] Univ Porto, Inst Res & Innovat Hlth I3S, Porto, Portugal

[15] Univ Porto, Fac Psychol & Educ Sci, Lab Neuropsychophysiol, Porto, Portugal

[16] Univ Med & Pharm Craiova, Dept Clin Pharm, Craiova 200349, Romania

来源：

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION | 2022年 / 62卷 / 29期

基金：

欧盟地平线“2020”;

关键词：

Flavonoids; anti-platelet aggregation; preclinical studies; mechanisms of action; signaling pathways; STIMULATED PLATELET ACTIVATION; TYPE-2; DIABETES-MELLITUS; GREEN TEA CATECHINS; ARACHIDONIC-ACID; DIETARY POLYPHENOLS; THROMBUS FORMATION; DARK CHOCOLATE; ESSENTIAL COMPONENTS; ARTERIAL THROMBOSIS; ALPHA-TOCOPHEROL;

D O I：

10.1080/10408398.2021.1924612

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Cardiovascular ailments are the number one cause of mortalities throughout the globe with 17.9 million deaths per year. Platelet activation and aggregation play a crucial role in the pathogenesis of arterial diseases, including acute coronary syndrome, acute myocardial infarction, cerebrovascular transient ischemia, unstable angina, among others. Flavonoids-rich plant extracts are gaining interest for treating the heart-related problems due to safe nature of these herbal extracts. Consumption of plant-food-derived bioactives, particularly flavonoids, has shown antithrombotic, and cardiovascular protective effects due to its anti-platelet activity. Preclinical and clinical trials have proven that flavonoid-rich plant extracts are protective against the cardiac ailments through anti-platelet aggregation activity. This review aims to highlight the anti-platelet aggregation potential of flavonoids with a key emphasis on the therapeutic efficacy in humans. The mechanism of flavonoids in preventing and treating cardiovascular diseases is also highlighted based on preclinical and clinical experimental trials. Further studies are the need of time for exploring the exact molecular mechanism of flavonoids as anti-platelet aggregation agents for treating heart-related problems.

引用

页码：8045 / 8058

页数：14

共 113 条

[91] A review of the mechanisms and effectiveness of dietary polyphenols in reducing oxidative stress and thrombotic risk [J].