TOR signalling in bugs, brain and brawn

被引：489

作者：

Jacinto, E ^{[1
]}

Hall, MN ^{[1
]}

机构：

[1] Univ Basel, Biozentrum, Div Biochem, CH-4056 Basel, Switzerland

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrm1018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

TOR-a highly conserved atypical protein kinase and the 'target of rapamycin', an immunosuppressant and anti-cancer drug-controls cell growth. TOR controls the growth of proliferating yeast, fly and mammalian cells in response to nutrients. Recent findings, however, indicate that TOR also controls the growth of non-proliferating cells, such as neurons and muscle cells. Furthermore, TOR, by associating with regulatory proteins and inhibiting phosphatases, controls the activity of multiphosphorylated effectors.

引用

页码：117 / 126

页数：10

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