Routes to, from and within the subiculum

被引:26
作者
Boehm, Claudia [1 ,2 ]
Peng, Yangfan [3 ,4 ]
Geiger, Joerg R. P. [3 ]
Schmitz, Dietmar [1 ,5 ,6 ,7 ]
机构
[1] Charite Univ Med Berlin, Neurosci Res Ctr, Berlin, Germany
[2] Janelia Res Campus, Ashburn, VA 20147 USA
[3] Charite Univ Med Berlin, Inst Neurophysiol, Berlin, Germany
[4] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany
[5] Cluster Excellence NeuroCure, Berlin, Germany
[6] Bernstein Ctr Computat Neurosci, Berlin, Germany
[7] Ctr Neurodegenerat Dis, Berlin, Germany
关键词
Hippocampus; Subiculum; Connectivity; Oscillation; Pyramidal cell; CA1 PYRAMIDAL NEURONS; SHARP-WAVE RIPPLES; HIPPOCAMPAL-FORMATION; ENTORHINAL CORTEX; PARAHIPPOCAMPAL REGION; LAMINAR ORGANIZATION; PERIRHINAL CORTEX; DORSAL SUBICULUM; SPATIAL MEMORY; DENTATE GYRUS;
D O I
10.1007/s00441-018-2848-4
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The subiculum is one of the major output areas of the hippocampus and has extensive projections to extrahippocampal targets. It is likely to play a pivotal role in the distribution of outgoing information from the hippocampus. The hippocampus, including the subiculum, is important for the formation, consolidation and retrieval of memory. These functions require a network that is flexible enough to encode incoming information and also allows for reliable distribution, storage and integration into previously encoded memories. Finally, relevant information has to be retrieved in a context-specific manner to allow for an appropriate behavioral response. The subiculum as a gateway between the hippocampus and cortex might serve to integrate and process information from the hippocampus proper and its other inputs before conveying it to more permanent storage locations. This review summarizes how the subiculum is embedded into upstream and downstream circuits, describes what is known about the local network topology and discusses cellular and functional properties of subicular cells subtypes. Lastly, it describes how these properties might help to separate information into parallel output streams and distribute it to its multiple target areas.
引用
收藏
页码:557 / 563
页数:7
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