Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging

被引:35
作者
Moore, Colman [1 ]
Chen, Fang [1 ,2 ]
Wang, Junxin [1 ]
Jokerst, Jesse V. [1 ,2 ,3 ]
机构
[1] Univ Calif San Diego, Dept NanoEngi, San Diego, CA 92093 USA
[2] Univ Calif San Diego, Mat Sci & Engn Program, San Diego, CA 92093 USA
[3] Univ Calif San Diego, Dept Radiol, San Diego, CA 92093 USA
基金
美国国家卫生研究院;
关键词
Photoacoustics; Ultrasound; Drug delivery; Nanopartides; SEMICONDUCTING POLYMER NANOPARTICLES; ACTIVATED CLOTTING TIME; REDUCED GRAPHENE OXIDE; MESENCHYMAL STEM-CELLS; CONTRAST AGENT; PHOTODYNAMIC THERAPY; MAGNETIC-RESONANCE; HEPARIN CONCENTRATION; SILICA NANOPARTICLES; GOLD NANOPARTICLES;
D O I
10.1016/j.addr.2019.07.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The preclinical landscape of photoacoustic imaging has experienced tremendous growth in the past decade. This non-invasive imaging modality augments the spatiotemporal capabilities of ultrasound with optical contrast. While it has principally been investigated for diagnostic applications, many recent reports have described theranostic delivery systems and drug monitoring strategies using photoacoustics. Here, we provide an overview of the progress to date while highlighting work in three specific areas: theranostic nanoparticles, real-time drug monitoring, and stem cell ("living drug") tracking. Additionally, we discuss the challenges that remain to be addressed in this burgeoning field. (C) 2019 Elsevier B.V. All rights reserved.
引用
收藏
页码:78 / 89
页数:12
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