Smad4/DPC4

被引：66

作者：

McCarthy, Aoife J.

Chetty, Runjan

机构：

[1] Univ Hlth Network, Dept Anat Pathol, Lab Med Program, Toronto, ON, Canada

[2] Univ Toronto, Toronto, ON, Canada

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2018年 / 71卷 / 08期

关键词：

HEREDITARY HEMORRHAGIC TELANGIECTASIA; TRANSFORMING GROWTH-FACTORS; HUMAN COLORECTAL-CANCER; TUMOR-SUPPRESSOR GENE; HEPATOCELLULAR-CARCINOMA; NEUROENDOCRINE TUMORS; PROGNOSTIC MARKER; PANCREATIC-CANCER; DPC4; INACTIVATION; PROSTATE-CANCER;

D O I：

10.1136/jclinpath-2018-205095

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Smad4 or DPC4 belongs to a family of signal transduction proteins that are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor beta (TGF-beta) signaling via several pathways. The gene acts as a tumour suppressor gene and inactivation of smad4/DPC4 is best recognised in pancreatic cancer. However, smad4/DPC4 is also mutated in other conditions and cancers such as juvenile polyposis syndrome with and without hereditary haemorrhagic telangiectasia, colorectal and prostate cancers. Immunohistochemistry for smad4/DPC4 protein is most useful in separating benign/reactive conditions from pancreatic cancer in needle/core biopsies. In normal and reactive states, the protein is localised to the cytoplasm and nucleus, while the protein is lost in high-grade pancreatic intraepithelial neoplasia/carcinoma in situ and pancreatic cancer.

引用

页码：661 / 664

页数：4

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