Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings

被引：58

作者：

Takahashi, Naoto ^{[1
]}

Uehara, Ritei ^{[2
]}

Kobayashi, Mami ^{[1
]}

Yada, Yukari ^{[1
]}

Koike, Yasunori ^{[1
]}

Kawamata, Ryou ^{[1
]}

Odaka, Jun ^{[1
]}

Honma, Yoko ^{[1
]}

Momoi, Mariko Y. ^{[1
]}

机构：

[1] Jichi Med Univ, Sch Med, Dept Pediat, Shimotsuke, Tochigi 3290498, Japan

[2] Jichi Med Univ, Sch Med, Dept Publ Hlth, Shimotsuke, Tochigi 3290498, Japan

来源：

CYTOKINE | 2010年 / 49卷 / 03期

关键词：

Cord blood; Newborn infants; Cytokine; Cytokine profile; COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; CHRONIC LUNG-DISEASE; PREMATURE-INFANTS; PRETERM INFANTS; INTERLEUKIN-6; CONCENTRATIONS; TRANSPLACENTAL PASSAGE; NEONATAL SEPSIS; INNATE IMMUNITY; PLASMA;

D O I：

10.1016/j.cyto.2009.11.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Few papers have investigated the cytokine profiles of multiple cytokines in cord blood. We obtained cord blood samples from 224 infants admitted to our neonatal intensive care unit. Cytokine profiles of 17 cytokines were investigated using cytometric bead array technology. We found a wide variety of cytokines of various levels which ranged from 0.59 pg/ml (in Interleukin (IL-4) to 222.0 pg/ml (in macrophage inflammatory protein-1 beta. Pro-inflammatory cytokines were highly correlated with each other and with granulocyte-colony stimulating factor and IL-8. On the contrary, IL-5, IL-13, and IL-17 did not show any significant correlation with other cytokines. Several maternal factors were strongly related to several cytokines in cord blood. IL-6, IL-8 and monocyte chemotactic protein-1 were closely related to certain neonatal diseases in preterm neonates. Some cytokines may be regulated independently of each other, while others appear to work as a network affecting physiological and pathological conditions in the fetus. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：331 / 337

页数：7

共 28 条

[1] Interleukin-6, interleukin-8, and soluble tumor necrosis factor receptor-I in the cord blood as predictors of chronic lung disease in premature infants [J].

An, H ;

Nishimaki, S ;

Ohyama, M ;

Haruki, A ;

Naruto, T ;

Kobayashi, N ;

Sugai, T ;

Kobayashi, Y ;

Mori, M ;

Seki, K ;

Yokota, S .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2004, 191 (05) :1649-1654

[2] Innate immunity of the human newborn is polarized toward a high ratio of IL-6/TNF-α production in vitro and in vivo [J].

Angelone, Donatella F. ;

Wessels, Michael R. ;

Coughlin, Melissa ;

Suter, Eugenie E. ;

Valentini, Piero ;

Kalish, Leslie A. ;

Levy, Ofer .

PEDIATRIC RESEARCH, 2006, 60 (02) :205-209

[3] Plasma levels and gene expression of granulocyte colony-stimulating factor, tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-8, and soluble intercellular adhesion molecule-1 in neonatal early onset sepsis [J].

Berner, R ;

Niemeyer, CM ;

Leititis, JU ;

Funke, A ;

Schwab, C ;

Rau, U ;

Richter, K ;

Tawfeek, MSK ;

Clad, A ;

Brandis, M .

PEDIATRIC RESEARCH, 1998, 44 (04) :469-477

[4] Perinatal plasma monocyte chemotactic protein-1 concentrations in intrauterine growth restriction [J].

Briana, Despina D. ;

Boutsikou, Maria ;

Baka, Stavroula ;

Papadopoulos, George ;

Gourgiotis, Dimitrios ;

Puchner, Karl Philipp ;

Hassiakos, Dimitrios ;

Malamitsi-Puchner, Ariadne .

MEDIATORS OF INFLAMMATION, 2007, 2007

[5] Transplacental passage of recombinant human granulocyte colony-stimulating factor in women with an imminent preterm delivery [J].

Calhoun, DA ;

Rosa, C ;

Christensen, RD .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1996, 174 (04) :1306-1311

[6] Intracellular cytokine profile of cord and adult blood lymphocytes [J].

Chalmers, IMH ;

Janossy, G ;

Contreras, M ;

Navarette, C .

BLOOD, 1998, 92 (01) :11-18

[7] Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions [J].

Duggan, PJ ;

Maalouf, EF ;

Watts, TL ;

Sullivan, MHF ;

Counsell, SJ ;

Allsop, J ;

Al-Nakib, L ;

Rutherford, MA ;

Battin, M ;

Roberts, I ;

Edwards, AD .

LANCET, 2001, 358 (9294) :1699-1700

[8] Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity [J].

Goepfert, AR ;

Andrews, WW ;

Carlo, W ;

Ramsey, PS ;

Cliver, SP ;

Goldenberg, RL ;

Hauth, JC .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2004, 191 (04) :1375-1381

[9] The fetal inflammatory response syndrome [J].

Gomez, R ;

Romero, R ;

Ghezzi, F ;

Yoon, BH ;

Mazor, M ;

Berry, SM .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1998, 179 (01) :194-202

[10] Circulating interferon-gamma and white matter brain damage in preterm infants [J].

Hansen-Pupp, I ;

Harling, S ;

Berg, AC ;

Cilio, C ;

Hellström-Westas, L ;

Ley, D .

PEDIATRIC RESEARCH, 2005, 58 (05) :946-952

← 1 2 3 →