Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor

被引：17

作者：

Hu, E ^{[1
]}

Chua, PC

Tehrani, L

Nagasawa, JY

Pinkerton, AB

Rowe, BA

Vernier, JM

Hutchinson, JH

Cosford, NDP

机构：

[1] Merck Res Labs, Dept Med Chem, San Diego, CA 92121 USA

[2] Merck Res Labs, Dept Mol Profiling, San Diego, CA 92121 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 20期

关键词：

metabotropic glutamate receptor; mGlu2; potentiator;

D O I：

10.1016/j.bmcl.2004.07.079

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Pyrimidine methyl anilines as potent and selective mGlu2 potentiators are described. Findings from the structure-activity-relationship investigations are discussed. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5071 / 5074

页数：4

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