A simple novel prognostic model for early stage oral tongue cancer

被引：92

作者：

Almangush, A. ^{[1
,2
]}

Coletta, R. D. ^{[3
]}

Bello, I. O. ^{[1
,4
]}

Bitu, C. ^{[5
]}

Keski-Santti, H. ^{[6
]}

Makinen, L. K. ^{[6
]}

Kauppila, J. H. ^{[7
,8
,9
]}

Pukkila, M. ^{[10
]}

Hagstrom, J. ^{[1
,11
]}

Laranne, J. ^{[12
]}

Tommola, S. ^{[13
]}

Soini, Y. ^{[14
]}

Kosma, V-M. ^{[14
]}

Koivunen, P. ^{[15
]}

Kowalski, L. P. ^{[16
]}

Nieminen, P. ^{[17
]}

Grenman, R. ^{[18
]}

Leivo, I. ^{[1
,22
]}

Salo, T. ^{[5
,19
,20
,21
]}

机构：

[1] Univ Helsinki, Haartman Inst, Dept Pathol, FIN-00014 Helsinki, Finland

[2] Univ Misurata, Inst Dent, Misurata, Libya

[3] Univ Estadual Campinas, Sch Dent, Dept Oral Diag, Sao Paulo, Brazil

[4] King Saud Univ, Dept Oral Med & Diagnost Sci, Riyadh, Saudi Arabia

[5] Univ Oulu, Inst Dent, Dept Diagnost & Oral Med, Oulu, Finland

[6] Univ Helsinki, Cent Hosp, Dept Otorhinolaryngol & Head & Neck Surg, FIN-00014 Helsinki, Finland

[7] Univ Oulu, Dept Surg, Oulu, Finland

[8] Univ Oulu, Dept Pathol, Oulu, Finland

[9] Oulu Univ Hosp, Oulu, Finland

[10] Kuopio Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, SF-70210 Kuopio, Finland

[11] Univ Helsinki, Inst Dent, Dept Oral Pathol, FIN-00014 Helsinki, Finland

[12] Tampere Univ Hosp, Dept Otorhinolaryngol & Head & Neck Surg, Tampere, Finland

[13] Tampere Univ Hosp, Dept Pathol, Tampere, Finland

[14] Univ Eastern Finland, Dept Pathol & Forens Med, Kuopio, Finland

[15] Oulu Univ, Cent Hosp, Dept Otorhinolaryngol & Head & Neck Surg, SF-90220 Oulu, Finland

[16] AC Camargo Canc Ctr, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo, Brazil

[17] Univ Oulu, Dept Med Informat & Stat, Oulu, Finland

[18] Univ Turku, Turku Univ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Turku, Finland

[19] Oulu Univ Hosp, Dept Diagnost & Oral Med, Oulu, Finland

[20] Med Res Ctr, Oulu, Finland

[21] Univ Helsinki, Inst Dent, FIN-00014 Helsinki, Finland

[22] Univ Turku, Dept Pathol, Turku, Finland

来源：

INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY | 2015年 / 44卷 / 02期

关键词：

oral tongue squamous cell carcinoma; prognosis; BD model; tumour budding; depth of invasion; SQUAMOUS-CELL CARCINOMA; LYMPH-NODE BIOPSY; NECK DISSECTION; TUMOR THICKNESS; POOR-PROGNOSIS; HEAD; METASTASIS; PARAMETERS; SURVIVAL;

D O I：

10.1016/j.ijom.2014.10.004

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The prognostication of patient outcome is one of the greatest challenges in the management of early stage oral tongue squamous cell carcinoma (OTSCC). This study introduces a simple histopathological model for the prognostication of survival in patients with early OTSCC. A total of 311 cases (from Finland and Brazil) with clinically evaluated early stage OTSCC (cT1-T2cN0cM0) were included in this multicentre retrospective study. Tumour budding (B) and depth of invasion (D) were scored on haematoxylin eosin-stained cancer slides. The cut-off point for tumour budding was set at 5 buds (low <5; high >= 5) and for depth of invasion at 4 mm (low <4 mm; high >= 4 mm). The scores of B and D were combined into one model: the BD predictive model. On multivariate analysis, a high risk score (BD score 2) correlated significantly with loco-regional recurrence (P = 0.033) and death due to OTSCC (P < 0.001) in early stage OTSCC. The new BD model is a promising prognostic tool to identify those patients with aggressive cases of early stage OTSCC who might benefit from multimodality treatment.

引用

页码：143 / 150

页数：8

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