D-mannose administration improves autoimmune hepatitis by upregulating regulatory T cells

被引：10

作者：

Ito, Daisuke ^{[1
]}

Ito, Hiroyasu ^{[2
]}

Ideta, Takayasu ^{[3
]}

Kanbe, Ayumu ^{[4
]}

Shimizu, Masahito ^{[1
]}

机构：

[1] Gifu Univ, Grad Sch Med, Dept Gastroenterol, Gifu, Yanagido 5011194, Japan

[2] Fujita Hlth Univ, Sch Med, Dept Joint Res Lab Clin Med, 1-98 Dengakugakubo, Aichi, Toyoake 4701192, Japan

[3] Gifu Univ, Grad Sch Med, Dept Informat Clin Med, Gifu, Yanagido 5011194, Japan

[4] Gifu Univ Hosp, Dept Clin Lab, Gifu, Yanagido 5011194, Japan

来源：

CELLULAR IMMUNOLOGY | 2022年 / 375卷

关键词：

D; -mannose; Regulatory T cell (Treg); Autoimmune hepatitis (AIH); Inflammation; Concanavalin A (ConA); -Galactosylceramide (GalCer); Indoleamine; 2; 3-dioxygenase (IDO); TGF-BETA; LIVER-INJURY; ALPHA; GENERATION; PROLIFERATION; SMAD7; VIVO; IDO;

D O I：

10.1016/j.cellimm.2022.104517

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A recent study revealed that D-mannose suppressed immunopathology in mouse models of autoimmune diabetes and airway inflammation and increased the proportion of regulatory T cells (Tregs) in mice. We investigated the effect of D-mannose on liver injury in murine autoimmune hepatitis (AIH) models induced by concanavalin A (ConA) and alpha-galactosylceramide (GalCer). Mouse models of AIH were created by intraperitoneal injection of GalCer or intravenous injection of ConA. Drinking water was supplemented with D-mannose and biochemically and pathologically examined over time. The administration of D-mannose to AIH model mice significantly reduced liver injury and reduced inflammatory cytokine expression. In addition, Tregs among splenocytes and intrahepatic lymphocytes were significantly increased by the administration of D-mannose. These results indicate that treatment with D-mannose reduced the inflammatory response in the liver and suppressed liver damage by increasing Tregs.

引用

页数：10

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