New steroidal alkaloids from Sarcococca saligna

被引：18
|
作者：
Rahman, A [1 ]
Choudhary, MI [1 ]
Khan, MR [1 ]
Anjum, S [1 ]
Farooq, A [1 ]
Iqbal, MZ [1 ]
机构：
[1] Univ Karachi, Natl Nematol Res Ctr, Int Ctr Chem Sci, Karachi 75270, Pakistan
来源：
JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期
关键词：
D O I：
10.1021/np990108w
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Five new pregnane-type steroidal alkaloids (1-5) have been isolated from Sarcococca saligna. A combination of UV, IR, MS, and 1D and 2D NMR spectroscopic studies established their structures as salignarine A [(20S);2 beta -hydroxy-4 beta -acetoxy-5 alpha ,6 alpha -epoxy-20-(dimethylamino)-3 beta-(tigloylamino)pregnane] (1), salignarine B [(20S)-2 beta -hydroxy-20-(dimethylamino)-3 beta-(tigloylamino)-pregn-5-ene] (2), salignarine C [(20S)-2 beta -hydroxy-20-(dimethylamino)-3 beta-(senecioylamino)-pregn-5-ene] (3), salignarine D [(20S)-20- dimethylamino)-3 beta-(senecioylamino)-5 alpha -pregn-16-ene] (4), and salignarine E [(20S)-20-(dimethlyamino-3 beta-(tigloylamino)-pregn-4-ene] (5), respectively.
引用
收藏
页码：1364 / 1368
页数：5
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