Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity

被引：66

作者：

El Newahie, Aliya M. S. ^{[1
]}

Ismail, Nasser S. M. ^{[2
]}

Abou El Ella, Dalal A. ^{[3
]}

Abouzid, Khaled A. M. ^{[3
]}

机构：

[1] October Univ Modern Sci & Arts MSA, Dept Organ Pharmaceut Chem, Fac Pharm, Cairo, Egypt

[2] Future Univ, Dept Pharmaceut Chem, Fac Pharmaceut Sci & Pharmaceut Ind, Cairo, Egypt

[3] Ain Shams Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo 11566, Egypt

来源：

ARCHIV DER PHARMAZIE | 2016年 / 349卷 / 05期

关键词：

Anticancer; Kinase inhibitors; Quinoxalines; SAR; Synthetic strategies; GROWTH-FACTOR RECEPTOR; ACUTE MYELOID-LEUKEMIA; INTERNAL TANDEM DUPLICATION; ONE-POT SYNTHESIS; BIOLOGICAL EVALUATION; INHIBITORY-ACTIVITY; POLYCYTHEMIA-VERA; CLINICAL-PROGRESS; FLT3; INHIBITORS; CDK4;

D O I：

10.1002/ardp.201500468

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date.

引用

页码：309 / 326

页数：18

共 115 条

[1] Molecular modeling studies and synthesis of novel quinoxaline derivatives with potential anticancer activity as inhibitors of c-Met kinase [J].

Abbas, Hebat-Allah S. ;

Al-Marhabi, Aisha R. ;

Eissa, Sally I. ;

Ammar, Yousry A. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (20) :6560-6572

[2] Review of Clinic Trials: Agents Targeting c-Met [J].

Abidoye, Oyewale ;

Murukurthy, Nadh ;

Salgia, Ravi .

REVIEWS ON RECENT CLINICAL TRIALS, 2007, 2 (02) :143-147

[3]

Amadeu F. B., 2001, J CHEM SOC PERK T, V2, P1315

[4] Direct and catalytic synthesis of quinoxaline derivatives from epoxides and ene-1,2-diamines [J].

Antoniotti, S ;

Duñach, E .

TETRAHEDRON LETTERS, 2002, 43 (22) :3971-3973

[5] Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805 [J].

Baffert, Fabienne ;

Regnier, Catherine H. ;

De Pover, Alain ;

Pissot-Soldermann, Carole ;

Tavares, Gisele A. ;

Blasco, Francesca ;

Brueggen, Josef ;

Chene, Patrick ;

Drueckes, Peter ;

Erdmann, Dirk ;

Furet, Pascal ;

Gerspacher, Marc ;

Lang, Marc ;

Ledieu, David ;

Nolan, Lynda ;

Ruetz, Stephan ;

Trappe, Joerg ;

Vangrevelinghe, Eric ;

Wartmann, Markus ;

Wyder, Lorenza ;

Hofmann, Francesco ;

Radimerski, Thomas .

MOLECULAR CANCER THERAPEUTICS, 2010, 9 (07) :1945-1955

[6] An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using molecular iodine as the catalyst [J].

Bhosale, RS ;

Sarda, SR ;

Ardhapure, SS ;

Jadhav, WN ;

Bhusare, SR ;

Pawar, RP .

TETRAHEDRON LETTERS, 2005, 46 (42) :7183-7186

[7] Met, metastasis, motility and more [J].

Birchmeier, C ;

Birchmeier, W ;

Gherardi, E ;

Vande Woude, GF .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (12) :915-925

[8]

Bridges AJ, 1999, CURR MED CHEM, V6, P825

[9] Gallium(III) triflate-catalyzed synthesis of quinoxaline derivatives [J].

Cai, Jing-Jing ;

Zou, Jian-Ping ;

Pan, Xiang-Qiang ;

Zhang, Wei .

TETRAHEDRON LETTERS, 2008, 49 (52) :7386-7390

[10] Chemistry, biological properties and SAR analysis of quinoxalinones [J].

Carta, A. ;

Piras, S. ;

Loriga, G. ;

Paglietti, G. .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2006, 6 (11) :1179-1200

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