Myeloid neoplasms with t(16;21)(q24;q22)/RUNX1-RUNX1T3 mimics acute myeloid leukemia with RUNX1-RUNX1T1

被引：14

作者：

Liu, Huifei ^{[1
,2
]}

Wang, Sa A. ^{[1
]}

Schlette, Ellen J. ^{[1
]}

Xu, Jie ^{[1
]}

Jorgensen, Jeffrey L. ^{[1
]}

Yin, C. Cameron ^{[1
]}

Li, Shaoying ^{[1
]}

Medeiros, L. Jeffrey ^{[1
]}

Tang, Guilin ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Hematopathol, 1515 Holcombe Blvd, Houston, TX 77030 USA

[2] Hematologics Inc, 3161 Elliott Ave,Suite 200, Seattle, WA 98121 USA

来源：

ANNALS OF HEMATOLOGY | 2018年 / 97卷 / 10期

关键词：

Myeloid neoplasms; RUNX1/RUNX1T3; rearrangement; t(16; 21); Therapy-related; ACUTE MYELOBLASTIC-LEUKEMIA; RUNX1-MTG16 FUSION GENE; HEMATOPOIETIC DISORDERS; T(16/21); AML; T(16-21)(Q24-Q22); IDENTIFICATION; ABNORMALITIES; TRANSLOCATION; MITOXANTRONE;

D O I：

10.1007/s00277-018-3389-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chromosome translocation t(16;21)(q24;q22)/RUNX1-RUNX1T3 is an infrequent but recurrent chromosomal abnormality identified in myeloid neoplasms, with only 25 cases have been reported to date. Here, we report eight cases (six women and two men) of myeloid neoplasms associated with t(16;21)(q24;q22): five with therapy-related myeloid neoplasms, two with relapsed acute myeloid leukemia (AML), and one with blast phase of chronic myeloid leukemia. Morphologic and immunophenotypic features include granulocytic dysplasia, blasts with prominent perinuclear hof, large orange-pink granules, long and slim Auer rods, and aberrant expression of CD19. Six patients received AML-based regimens, and five achieved complete remission after initial induction therapy. Our study suggests that myeloid neoplasm with t(16;21)/RUNX1-RUNX1T1 resembles AML with t(8;21)(q22;q22)/RUNX1-RUNX1T1, in regard to morphology, immunophenotype, and response to therapy. Therefore, the clinical management of AML with t(8;21) may provide the best model for patients with myeloid neoplasms with t(16;21).

引用

页码：1775 / 1783

页数：9

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