Regulating the construction and demolition of the synaptonemal complex

被引：168
作者：
Cahoon, Cori K. [1 ]
Hawley, R. Scott [1 ,2 ]
机构：
[1] Stowers Inst Med Res, Kansas City, MO USA
[2] Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66103 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2016年 / 23卷 / 05期
关键词：
CHROMOSOMAL PASSENGER COMPLEX; MEIOTIC CROSSING-OVER; DOUBLE-STRAND BREAKS; POLO-LIKE KINASE; AURORA-B KINASE; C-ELEGANS; CROSSOVER INTERFERENCE; SYNAPSIS INITIATION; HOMOLOG ALIGNMENT; CHIASMA FORMATION;
D O I：
10.1038/nsmb.3208
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous chromosomes from end to end during meiotic prophase and is required for the formation of meiotic crossovers. Assembly of SC components is regulated by a combination of associated nonstructural proteins and post-translational modifications, such as SUMOylation, which together coordinate the timing between homologous chromosome pairing, double-strand-break formation and recombination. In addition, transcriptional and translational control mechanisms ensure the timely disassembly of the SC after crossover resolution and before chromosome segregation at anaphase I.
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收藏
页码：369 / 377
页数：9
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