A series of octahedral phenanthroline cobalt chlorides, aqua and carbonates complexes have been prepared, characterized, and their antibacterial activity was studied in detail in terms of zone inhibition and minimum inhibitory concentrations. Their antioxidant activities were studied by measuring DPPH, SOD and ABTS radical scavenging activity. It was found that cobalt phenanthroline carbonate complex possessed highest antibacterial activity, antioxidant activity, degradation effect on DNA and showed moderate cytotoxicity against Hepatocellular carcinoma (HEPG-2), Mammary gland (MCF-7) and Colorectal carcinoma (HCT-116) cells. The complexes were studied with UV spectroscopy to observe the solvents effect on the electronic spectra. Equation that relates peak position lambda max to solvent parameters are solved by computerized analysis using multiple regression techniques, and the correlation and regression coefficients were evaluated. The independent solvent parameters used are H-bonding ability, refractive index and dielectric constant. The FTIR spectrum was interpreted according to the actual structure. (C) 2018 Production and hosting by Elsevier B.V.
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页码:1061 / 1069
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Agwara MO, 2010, B CHEM SOC ETHIOPIA, V24, P383
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Mansoura Univ, Dept Chem, Fac Sci, Mansoura 35516, EgyptKing Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hufuf 31982, Al Ahsa, Saudi Arabia
Youssef, Magdy M.
Al-Omair, Mohammed A.
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King Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hufuf 31982, Al Ahsa, Saudi ArabiaKing Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hufuf 31982, Al Ahsa, Saudi Arabia
机构:
Mansoura Univ, Dept Chem, Fac Sci, Mansoura 35516, EgyptKing Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hufuf 31982, Al Ahsa, Saudi Arabia
Youssef, Magdy M.
Al-Omair, Mohammed A.
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h-index: 0
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King Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hufuf 31982, Al Ahsa, Saudi ArabiaKing Faisal Univ, Coll Sci, Dept Chem, POB 400, Al Hufuf 31982, Al Ahsa, Saudi Arabia