Biochemical activities and electronic spectra of different cobalt phenanthroline complexes

被引：12
作者：
Al-Omair, Mohammed A. [1 ]
机构：
[1] King Faisal Univ, Coll Sci, Dept Chem, Al Hasa 31982, Saudi Arabia
来源：
ARABIAN JOURNAL OF CHEMISTRY | 2019年 / 12卷 / 07期
关键词：
1,10-Phenanthroline; Co(II) complexes; FTIR; Antibacteria; Antioxidant; Anticancer; Electronic spectra; MIXED-LIGAND COMPLEXES; ANTIOXIDANT ACTIVITY; CRYSTAL-STRUCTURE; 1,10-PHENANTHROLINE;
D O I：
10.1016/j.arabjc.2018.11.006
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of octahedral phenanthroline cobalt chlorides, aqua and carbonates complexes have been prepared, characterized, and their antibacterial activity was studied in detail in terms of zone inhibition and minimum inhibitory concentrations. Their antioxidant activities were studied by measuring DPPH, SOD and ABTS radical scavenging activity. It was found that cobalt phenanthroline carbonate complex possessed highest antibacterial activity, antioxidant activity, degradation effect on DNA and showed moderate cytotoxicity against Hepatocellular carcinoma (HEPG-2), Mammary gland (MCF-7) and Colorectal carcinoma (HCT-116) cells. The complexes were studied with UV spectroscopy to observe the solvents effect on the electronic spectra. Equation that relates peak position lambda max to solvent parameters are solved by computerized analysis using multiple regression techniques, and the correlation and regression coefficients were evaluated. The independent solvent parameters used are H-bonding ability, refractive index and dielectric constant. The FTIR spectrum was interpreted according to the actual structure. (C) 2018 Production and hosting by Elsevier B.V.
引用
收藏
页码：1061 / 1069
页数：9
相关论文
共 32 条
[1]  
Agwara MO, 2010, B CHEM SOC ETHIOPIA, V24, P383
[2]  
[Anonymous], 1989, Molecular Cloning
[3]   DISTRIBUTION OF IRON-CONTAINING SUPEROXIDE-DISMUTASE IN VASCULAR PLANTS [J].
BRIDGES, SM ;
SALIN, ML .
PLANT PHYSIOLOGY, 1981, 68 (02) :275-278
[4]  
Djuikom S. Y. G., 2016, INORG CHEM, V2, P1
[5]  
Dong Z, 2018, ROY SOC OPEN SCI, V5
[6]   Synthesis, characterization, equilibrium study and biological activity of Cu(II), Ni(II) and Co(II) complexes of polydentate Schiff base ligand [J].
El-Sherif, Ahmed A. ;
Shehata, Mohamed R. ;
Shoukry, Mohamed M. ;
Barakat, Mohammad H. .
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2012, 96 :889-897
[7]   Synthesis, antimicrobial, DNA cleavage and antioxidant activities of tricyclic sultams derived from saccharin [J].
Elghamry, Ibrahim ;
Youssef, Magdy M. ;
Al-Omair, Mohammed A. ;
Elsawy, Hany .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 139 :107-113
[8]   SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF 2-p-TOLYL-1H-IMIDAZO[4,5f][1,10] PHENANTHROLINE AND ITS Co(II), Ni(II) AND Cu(II) COMPLEXES [J].
Gomleksiz, Mesut ;
Alkan, Cihan ;
Erdem, Belgin .
BULLETIN OF THE CHEMICAL SOCIETY OF ETHIOPIA, 2013, 27 (02) :213-220
[9]  
Hassan H.H, 2006, SPECTROCHIM ACTA A, V63, P255
[10]   Dichlorobis(1,10-phenanthroline-N,N')cobalt(II)-acetonitrile (1/1.5) [J].
Hazell, A ;
McGinley, J ;
McKenzie, CJ .
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 :723-725
1234