Liver expression of matrix metalloproteases and their inhibitors in hepatocellular carcinoma

被引：47

作者：

Altadill, A. ^{[2
]}

Rodriguez, M. ^{[3
]}

Gonzalez, L. O. ^{[2
,4
,5
]}

Junquera, S. ^{[2
]}

Corte, M. D. ^{[2
]}

Gonzalez-Dieguez, M. L. ^{[3
]}

Linares, A. ^{[3
]}

Barbon, E. ^{[1
]}

Fresno-Forcelledo, M. ^{[6
]}

Rodrigo, L. ^{[3
]}

Vizoso, F. J. ^{[1
,2
,5
]}

机构：

[1] Gen Hosp Jove, Serv Cirugia, Gijon 33920, Asturias, Spain

[2] Gen Hosp Jove, Unidad Invest, Gijon 33920, Asturias, Spain

[3] Hosp Univ Cent Asturias, Serv Gastroenterol, Oviedo, Spain

[4] Gen Hosp Jove, Serv Anat Patol, Gijon 33920, Asturias, Spain

[5] Inst Univ Oncol Principado Asturias, Oviedo, Spain

[6] Hosp Univ Cent Asturias, Serv Anat Patol, Oviedo, Spain

来源：

DIGESTIVE AND LIVER DISEASE | 2009年 / 41卷 / 10期

关键词：

Hepatocellular carcinoma (HCC); Matrix metalloproteases (MMPs); Prognosis; Tissue inhibitors of metalloproteinases (TIMPs); FIBROTIC HUMAN LIVER; BREAST-CANCER; TUMOR PROGRESSION; TISSUE INHIBITOR; DIFFERENTIAL EXPRESSION; INTRAHEPATIC RECURRENCE; COLLAGENASE-3; MMP-13; EXTRACELLULAR-MATRIX; E-CADHERIN; METASTASIS;

D O I：

10.1016/j.dld.2009.01.016

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Several studies have suggested the significance of some metalloproteases in the malignant behaviour of hepatocellular carcinoma. Aims: To evaluate the liver expression of MMPs and their tissular inhibitors in patients with HCC. Methods: An immunohistochemical study using tissue microarrays on samples obtained from 30 HCC patients, with antibodies against MMPs (1, 2, 7, 9, 11, 13 and 14) and TIMPs (1,2 and 3) was performed. Results were correlated with various clinico-pathological findings and with overall survival. Results: MMP-1 is mainly expressed by stromal cells, and MMP-13, TIMP-1 and TIMP-2 by inflammatory cells. A positive correlation between MMP-1 expression and larger size tumours (p < 0.01) was found. Increased TIMP-2 expression was associated with higher preoperative serum levels of alpha-fetoprotein (p < 0.01). Unsupervised hierarchical clustering for total score values designated two groups, one of them characterised by high MMPs and TIMPs expressions, including 21 cases (70%) for tumour cell clustering. 5 cases for fibroblasts (16.6%) and 6 cases for inflammatory cells (20%). All patients showing elevated MMPs and TIMPs expression in stromal cells presented a poor prognosis (p < 0.05). Conclusions: High liver MMPs and TIMPs expressions in peritumour stromal cells are related to a poorer prognosis in HCC. (C) 2009 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：740 / 748

页数：9

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