A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes

被引：605
作者：
Sivakumar, K [1 ]
Xie, F [1 ]
Cash, BM [1 ]
Long, S [1 ]
Barnhill, HN [1 ]
Wang, Q [1 ]
机构：
[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 24期
关键词：
D O I：
10.1021/ol047955x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
[GRAPHICS] Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications.
引用
收藏
页码：4603 / 4606
页数：4
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