A fluorogenic 1,3-dipolar cycloaddition reaction of 3-azidocoumarins and acetylenes

被引：608

作者：

Sivakumar, K ^{[1
]}

Xie, F ^{[1
]}

Cash, BM ^{[1
]}

Long, S ^{[1
]}

Barnhill, HN ^{[1
]}

Wang, Q ^{[1
]}

机构：

[1] Univ S Carolina, Dept Chem & Biochem, Columbia, SC 29208 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 24期

关键词：

D O I：

10.1021/ol047955x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Copper(I)-catalyzed 1,3-dipolar cycloaddition reaction of nonfluorescent 3-azidocoumarins and terminal alkynes afforded intense fluorescent 1,2,3-triazole products. The mild condition of this reaction allowed us to construct a large library of pure fluorescent coumarin dyes. Since both azide and alkyne are quite inert to biological systems, this reaction has potential in bioconjugation and bioimaging applications.

引用

页码：4603 / 4606

页数：4

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