Comparison of simultaneous and sequential administration of fentanyl-propofol for surgical abortion: a randomized single-blinded controlled trial

被引：11

作者：

Gao, Wei ^{[1
]}

Sha, Baoyong ^{[2
]}

Zhao, Yuan ^{[1
]}

Fan, Zhe ^{[1
]}

Liu, Lin ^{[1
]}

Shen, Xin ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesiol, 277 Yanta West Rd, Xian, Shaanxi, Peoples R China

[2] Xian Med Univ, Sch Basic Med Sci, 1 Xinwang Rd, Xian, Shaanxi, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

Fentanyl; propofol; lipid emulsion; sedation; analgesia; surgical abortion; ANESTHESIA; MANAGEMENT; SEDATION; KETOFOL; PAIN; SHOT;

D O I：

10.1080/21691401.2016.1239106

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Propofol lipid emulsion (PLE) is a nanosized sedative, and it is used with a combination of salted antalgic prodrug, fentanyl citrate (FC). To illustrate the synergistic effect of mixing, we compared the sedation/analgesia resulting from simultaneous and sequential administration in surgically induced abortion (No. ChiCTR-IPC-15006153). Simultaneous group showed lower bispectral index, blood pressure, and heart rate, when cannula was inserted into the uterus. It also showed less frequency of hypertension, sinus tachycardia, movement, pain at the injection site, and additional FC. Therefore, premixing of PLE and FC enhanced the sedation and analgesia; stabilized the hemodynamics; lessened the incidence of movement and injection pain; and reduced the requirement of drugs.

引用

页码：1045 / 1050

页数：6

共 26 条

[1] Adabi M., 2016, Artificial Cells, Nanomedicine, and Biotechnology, V44, P1049
[2] Ahmad N, 2008, Med J Malaysia, V63, P431
[3] Surgical stress index reflects surgical stress in gynaecological laparoscopic day-case surgery
Ahonen, J.
Jokela, R.
Uutela, K.
Huiku, M.
[J]. BRITISH JOURNAL OF ANAESTHESIA, 2007, 98 (04) : 456 - 461
[4] Propofol - The challenges of formulation
Baker, MT
Naguib, M
[J]. ANESTHESIOLOGY, 2005, 103 (04) : 860 - 876
[5] AGA institute review of endoscopic sedation
Cohen, Lawrence B.
Delegge, Mark H.
Aisenberg, James
Brill, Joel V.
Inadomi, John M.
Kochman, Michael L.
Piorkowski, Joseph D., Jr.
[J]. GASTROENTEROLOGY, 2007, 133 (02) : 675 - 701
[6] The safety of deep sedation without intubation for abortion in the outpatient setting
Dean, Gillian
Jacobs, Adam R.
Goldstein, Robert C.
Gevirtz, Clifford M.
Paul, Maureen E.
[J]. JOURNAL OF CLINICAL ANESTHESIA, 2011, 23 (06) : 437 - 442
[7] Reduction in the incidence of awareness using BIS monitoring
Ekman, A
Lindholm, ML
Lennmarken, C
Sandin, R
[J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 2004, 48 (01) : 20 - 26
[8] Gao W, 2016, J NANOMATER, V2016, P8
[9] The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Gao, Wei
Sha, Baoyong
Liu, Yongchun
Wu, Daocheng
Shen, Xin
Jing, Guixia
[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2015, 43 (03) : 196 - 202
[10] An audit of the haemodynamic and emergence characteristics of single-shot 'ketofol'
Grace, R. F.
Tang, D. W.
Namel, E.
[J]. ANAESTHESIA AND INTENSIVE CARE, 2015, 43 (04) : 503 - 505

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