Comparison of simultaneous and sequential administration of fentanyl-propofol for surgical abortion: a randomized single-blinded controlled trial

被引：12

作者：

Gao, Wei ^{[1
]}

Sha, Baoyong ^{[2
]}

Zhao, Yuan ^{[1
]}

Fan, Zhe ^{[1
]}

Liu, Lin ^{[1
]}

Shen, Xin ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Anesthesiol, 277 Yanta West Rd, Xian, Shaanxi, Peoples R China

[2] Xian Med Univ, Sch Basic Med Sci, 1 Xinwang Rd, Xian, Shaanxi, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

Fentanyl; propofol; lipid emulsion; sedation; analgesia; surgical abortion; ANESTHESIA; MANAGEMENT; SEDATION; KETOFOL; PAIN; SHOT;

D O I：

10.1080/21691401.2016.1239106

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Propofol lipid emulsion (PLE) is a nanosized sedative, and it is used with a combination of salted antalgic prodrug, fentanyl citrate (FC). To illustrate the synergistic effect of mixing, we compared the sedation/analgesia resulting from simultaneous and sequential administration in surgically induced abortion (No. ChiCTR-IPC-15006153). Simultaneous group showed lower bispectral index, blood pressure, and heart rate, when cannula was inserted into the uterus. It also showed less frequency of hypertension, sinus tachycardia, movement, pain at the injection site, and additional FC. Therefore, premixing of PLE and FC enhanced the sedation and analgesia; stabilized the hemodynamics; lessened the incidence of movement and injection pain; and reduced the requirement of drugs.

引用

页码：1045 / 1050

页数：6

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