Synthesis, antibacterial properties and bioinformatics computational analyses of novel 8-hydroxyquinoline derivatives

被引:38
作者
Rbaa, Mohamed [1 ]
Jabli, Siham [2 ]
Lakhrissi, Younes [1 ]
Ouhssine, Mohamed [2 ]
Almalki, Faisal [3 ]
Ben Hadda, Taibi [3 ]
Messgo-Moumene, Saida [4 ]
Zarrouk, Abbelkader [5 ]
Lakhrissi, Brahim [1 ]
机构
[1] Ibn Tofail Univ, Fac Sci, Dept Chem, Lab Agroresources Polymers & Proc Engn, POB 133, Kenitra 14000, Morocco
[2] Ibn Tofail Univ, Fac Sci, Dept Biol, Lab Agro Physiol Biotechnol Environm & Qual, POB 133, Kenitra 14000, Morocco
[3] Umm Al Qura Univ, Fac Pharm, Dept Pharmaceut Chem, Makkah El Mukarramah, Saudi Arabia
[4] Univ Blida 1, Lab Res Med & Aromat Plants, Sci & Life Fac, POB 270,Soumaa Rd, Blida 09100, Algeria
[5] Mohammed V Univ, Fac Sci, Lab Mat Nanotechnol & Environm, Ibn Battouta Ave,POB 1014, Rabat, Morocco
关键词
Biochemistry; Microbiology; 8-hydroxyquinoline; Characterization; Antimicrobial activity; Antibacterial pharmacophore site; POM (Petra/Osiris/Molinspiration) analyses; MILD-STEEL; CORROSION; INHIBITION;
D O I
10.1016/j.heliyon.2019.e02689
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
New heterocyclic derivatives of 8-hydroxyquinoline were prepared and screened as antimicrobial agents. Chemical structures were elucidated and confirmed using different spectroscopic methods such as elemental analysis data, Infrared, Nuclear Magnetic Resonance Spectroscopy. In order to explore their potential biological activity, the "in vitro "antibacterial activity was investigated against [E. coli (ATCC35218), S. aureus (ATCC29213), V. parahaemolyticus (ATCC17802), and P. aeruginosa (ATCC27853)]. The studied compounds exhibited a remarkable antibacterial activity superior to the standard antibiotic (Penicillin G). These new heterocyclic derivatives of 8-hydroxyquinoline, which proved to be potentially effective, can be used as alternative chemical antimicrobial agents applications. It was very interesting to observe that POM (Petra/Osiris/Molinspiration) bioinformatic analyses of the 8-hydroxyquinoline derivative (5) exhibited more important antibacterial activity (MIC = 10(-6) mg/mL against V.p and S.a bacteria) and good drug score (DS = 0.71) when compared with Penicillin (DS = 0.33; MIC = 10(-3) mg/mL).
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页数:6
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