Transition-Metal-Free Electrophilic Amination between Aryl Grignard Reagents and N-Chloroamines

被引：100

作者：

Hatakeyama, Takuji ^{[1
]}

Yoshimoto, Yuya ^{[1
]}

Ghorai, Sujit K. ^{[1
]}

Nakamura, Masaharu ^{[1
]}

机构：

[1] Kyoto Univ, Int Res Ctr Elements Sci, Inst Chem Res, Kyoto 6110011, Japan

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

关键词：

MICROWAVE-ASSISTED AMINATION; ALPHA-AMINO-ACIDS; CATALYZED SYNTHESIS; C-N; HALIDES; ARYLMAGNESIUM; ARYLAMINES; AMIDATION; COUPLINGS; CHLORIDES;

D O I：

10.1021/ol100235b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of N,N,N,N-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl Grignard reagents to give a variety of arylamines in good to excellent yields. Functional groups such as ester and nitrile are compatible under the reaction conditions.

引用

页码：1516 / 1519

页数：4

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