Prenatal dietary choline availability alters postnatal neurotoxic vulnerability in the adult rat

被引：24
作者：
Guo-Ross, SX
Jones, KH
Shetty, AK
Wilson, WA
Swartzwelder, HS
机构：
[1] Vet Affairs Med Ctr, Neurobiol Res Lab, Durham, NC 27705 USA
[2] Duke Univ, Med Ctr, Dept Psychiat, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Dept Pharmacol, Durham, NC 27710 USA
[5] Duke Univ, Dept Psychol, Durham, NC 27710 USA
来源：
NEUROSCIENCE LETTERS | 2003年 / 341卷 / 02期
关键词：
choline; neurotoxicity; cingulate; N-methyl-D-aspartate receptor antagonist dizocilpine; supplementation; deficiency;
D O I：
10.1016/S0304-3940(03)00119-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a six-day gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of adult female rats produced by systemic administration of the N-methyl-D-aspartate receptor antagonist dizocilpine (MK-801). These data show that availability of choline during a brief prenatal period diminishes vulnerability to neurotoxicity in adult offspring. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：161 / 163
页数：3
相关论文
共 14 条
[1]   Developmental neuroscience - Choline, a vital amine [J].
Blusztajn, JK .
SCIENCE, 1998, 281 (5378) :794-795
[2]   Prenatal availability of choline alters the development of acetylcholinesterase in the rat hippocampus [J].
Cermak, JM ;
Blusztajn, JK ;
Meck, WH ;
Williams, CL ;
Fitzgerald, CM ;
Rosene, DL ;
Loy, R .
DEVELOPMENTAL NEUROSCIENCE, 1999, 21 (02) :94-104
[3]   Prenatal choline supplementation protects against postnatal neurotoxicity [J].
Guo-Ross, SX ;
Clark, S ;
Montoya, DAC ;
Jones, KH ;
Obernier, J ;
Shetty, AK ;
White, AM ;
Blusztajn, JK ;
Wilson, WA ;
Swartzwelder, HS .
JOURNAL OF NEUROSCIENCE, 2002, 22 (01)
[4]   Dietary choline supplementation in pregnant rats increases hippocampal phospholipase D activity of the offspring [J].
Holler, T ;
Cermak, JM ;
Blusztajn, JK .
FASEB JOURNAL, 1996, 10 (14) :1653-1659
[5]   Choline availability to the developing rat fetus alters adult hippocampal long-term potentiation [J].
Jones, JP ;
Meck, WH ;
Williams, CL ;
Wilson, WA ;
Swartzwelder, HS .
DEVELOPMENTAL BRAIN RESEARCH, 1999, 118 (1-2) :159-167
[6]   PRENATAL AND POSTNATAL CHOLINE SUPPLEMENTATION PRODUCES LONG-TERM FACILITATION OF SPATIAL MEMORY [J].
MECK, WH ;
SMITH, RA ;
WILLIAMS, CL .
DEVELOPMENTAL PSYCHOBIOLOGY, 1988, 21 (04) :339-353
[7]   Characterization of the facilitative effects of perinatal choline supplementation on timing and temporal memory [J].
Meck, WH ;
Williams, CL .
NEUROREPORT, 1997, 8 (13) :2831-2835
[8]   Prenatal choline supplementation alters hippocampal N-methyl-D-aspartate receptor-mediated neurotransmission in adult rats [J].
Montoya, D ;
Swartzwelder, HS .
NEUROSCIENCE LETTERS, 2000, 296 (2-3) :85-88
[9]   Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats [J].
Pyapali, GK ;
Turner, DA ;
Williams, CL ;
Meck, WH ;
Swartzwelder, HS .
JOURNAL OF NEUROPHYSIOLOGY, 1998, 79 (04) :1790-1796
[10]   Fluoro-Jade: A novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration [J].
Schmued, LC ;
Albertson, C ;
Slikker, W .
BRAIN RESEARCH, 1997, 751 (01) :37-46
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