Dynamic operation of optical fibres beyond the single-mode regime facilitates the orientation of biological cells

被引:62
作者
Kreysing, Moritz [1 ,2 ]
Ott, Dino [1 ,3 ]
Schmidberger, Michael J. [1 ,4 ,5 ]
Otto, Oliver [1 ,6 ]
Schuermann, Mirjam [6 ]
Martin-Badosa, Estela [7 ]
Whyte, Graeme [1 ,5 ]
Guck, Jochen [1 ,6 ]
机构
[1] Univ Cambridge, Cavendish Lab, Dept Phys, Cambridge CB3 0HE, England
[2] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany
[3] Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark
[4] Max Planck Inst Sci Light, D-91058 Erlangen, Germany
[5] Univ Erlangen Nurnberg, Dept Phys, D-91052 Erlangen, Germany
[6] Tech Univ Dresden, Ctr Biotechnol, D-01307 Dresden, Germany
[7] Univ Barcelona, Dept Appl Phys & Opt, E-08028 Barcelona, Spain
基金
欧洲研究理事会;
关键词
LIGHT; TRANSMISSION; MANIPULATION; PARTICLES; SYSTEM; CHIP;
D O I
10.1038/ncomms6481
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The classical purpose of optical fibres is delivery of either optical power, as for welding, or temporal information, as for telecommunication. Maximum performance in both cases is provided by the use of single-mode optical fibres. However, transmitting spatial information, which necessitates higher-order modes, is difficult because their dispersion relation leads to dephasing and a deterioration of the intensity distribution with propagation distance. Here we consciously exploit the fundamental cause of the beam deterioration-the dispersion relation of the underlying vectorial electromagnetic modes-by their selective excitation using adaptive optics. This allows us to produce output beams of high modal purity, which are well defined in three dimensions. The output beam distribution is even robust against significant bending of the fibre. The utility of this approach is exemplified by the controlled rotational manipulation of live cells in a dual-beam fibre-optical trap integrated into a modular lab-on-chip system.
引用
收藏
页数:6
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