Strategies for the Total Synthesis of the Furanosteroids: wortmannin and viridin

被引：3
|
作者：
Xue, Dongsheng [1 ]
He, Haibing [2 ]
Gao, Shuanhu [1 ,2 ]
机构：
[1] East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China
[2] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, 3663N Zhongshan Rd, Shanghai 200062, Peoples R China
来源：
CHEMISTRY LETTERS | 2021年 / 50卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Wortmannin; Viridin; Total synthesis; FORMAL TOTAL-SYNTHESIS; PHOSPHOINOSITIDE; 3-KINASE; CORE; RING; (+)-WORTMANNIN; HALENAQUINONE; XESTOQUINONE; EXIGUAQUINOL; INHIBITION; SPONGE;
D O I：
10.1246/cl.200841
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the allcarbon quaternary center in order to achieve total syntheses of wortmannin and viridin.
引用
收藏
页码：497 / 502
页数：6
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