Prechemotherapy alterations in brain function in women with breast cancer

被引：130

作者：

Cimprich, Bernadine ^{[1
,2
]}

Reuter-Lorenz, Patricia ^{[3
]}

Nelson, James ^{[4
]}

Clark, Patricia M. ^{[2
]}

Therrien, Barbara

Normolle, Daniel ^{[5
]}

Berman, Marc G. ^{[3
]}

Hayes, Daniel F. ^{[2
,6
]}

Noll, Douglas C. ^{[7
]}

Peltier, Scott ^{[7
]}

Welsh, Robert C. ^{[8
]}

机构：

[1] Univ Michigan, Sch Nursing, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Ctr Comprehens Canc, Breast Oncol Program, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Psychol, Ann Arbor, MI USA

[4] Dartmouth Coll, Dept Educ, Hanover, MA USA

[5] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA

[6] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[7] Univ Michigan, Dept Biomed Engn, Ann Arbor, MI 48109 USA

[8] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY | 2010年 / 32卷 / 03期

关键词：

Breast cancer; Cognitive function; Selective attention; Working memory; Adjuvant chemotherapy; Functional magnetic resonance imaging; RECEIVING ADJUVANT CHEMOTHERAPY; COGNITIVE FUNCTION; ANTERIOR CINGULATE; RESTORE ATTENTION; PREFRONTAL CORTEX; SYMPTOM DISTRESS; AGE-DIFFERENCES; INTERVENTION; METAANALYSIS; MAINTENANCE;

D O I：

10.1080/13803390903032537

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Despite clinical reports of cognitive deficits associated with cancer chemotherapy, the underlying brain mechanisms are not clear. This research examined selective attention and working memory using functional magnetic resonance imaging (fMRI) in women before chemotherapy for localized breast cancer. Patients were tested with an established selective attention and working memory task during fMRI. Compared with healthy controls, patients showed (a) bilateral brain activation in high-demand task conditions with recruitment of additional components of attention/working memory circuitry, and (b) less accurate and slower task performance. Results indicate compromised cognitive functioning before any chemotherapy and raise key questions for further research.

引用

页码：324 / 331

页数：8

共 61 条

[1] Cognitive effects of standard-dose chemotherapy in patients with cancer [J].