Enantioselective Total Synthesis of the Lignan (+)-Linoxepin

被引：12

作者：

Tietze, Lutz F. ^{[1
]}

Clerc, Jerome ^{[1
]}

Biller, Simon ^{[1
]}

Duefert, Svenia-C. ^{[1
]}

Bischoff, Matthias ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 51期

关键词：

asymmetric hydroboration; carbopalladation; lignans; natural products; total synthesis; DOMINO REACTIONS; NATURAL-PRODUCTS; ASYMMETRIC HYDROBORATION; ORGANIC-SYNTHESIS; CHEMISTRY; LIGANDS; ALKENES; HYDROGENATION; ARYLATIONS; DRUGS;

D O I：

10.1002/chem.201404679

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An enantioselective total synthesis of the natural (+)-linoxepin (1) was accomplished in eleven steps from bromovanin (24). Key steps are a domino carbopalladation/ Mizoroki-Heck reaction with the formation of a pentacyclic system, an asymmetric hydroboration as well as an oxidative lactonization.

引用

页码：17119 / 17124

页数：6

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