Diagnostic Tests for Latent Tuberculosis Infection

被引：64

作者：

Haas, Michelle K. ^{[1
,2
]}

Belknap, Robert W. ^{[1
,2
]}

机构：

[1] Denver Publ Hlth, Denver Metro TB Program, 605 Bannock St, Denver, CO 80204 USA

[2] Univ Colorado, Dept Med, Div Infect Dis, Anschutz Med Campus,13001 E 17th Pl, Aurora, CO 80045 USA

来源：

CLINICS IN CHEST MEDICINE | 2019年 / 40卷 / 04期

关键词：

Latent tuberculosis infection; LTBI; Tuberculin skin test; TST; Interferon-gamma release assay; QuantiFERON; T-SPOT.TB; GAMMA RELEASE ASSAYS; QUANTIFERON-TB GOLD; HEALTH-CARE WORKERS; SKIN-TEST; PREDICTIVE-VALUE; UNITED-STATES; DISEASE; ADULTS; PLUS; PERFORMANCE;

D O I：

10.1016/j.ccm.2019.07.007

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Diagnosing latent tuberculosis (TB) infection (LTBI) is important globally for TB prevention. LTBI diagnosis requires a positive test for infection and negative evaluation for active disease. Current tests measure an immunologic response and include the tuberculin skin test (TST) and interferon-gamma release assays (IGRAs), T-SPOT.TB and QuantiFERON. The IGRAs are preferred in bacille Calmette-Guerin-vaccinated populations. The TST is still used when cost or logistical advantages over the IGRAs exist. Both TST and IGRAs have low positive predictive values. Tests that differentiate the TB spectrum and better predict future TB risk are needed.

引用

页码：829 / +

页数：10

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