Solid-phase synthesis of doubly labeled peptide nucleic acids as probes for the real-time detection of hybridization

被引：1
作者：
Seitz, O
机构：
[1] Max Planck Inst Mol Physiol, Abt Chem Biol, D-44227 Dortmund, Germany
[2] Univ Dortmund, Inst Organ Chem, Dortmund, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 18期
关键词：
DNA recognition; donor-acceptor systems; fluorescence spectroscopy; nucleic acids; solid-phase synthesis;
D O I：
10.1002/1521-3773(20000915)39:18<3249::AID-ANIE3249>3.0.CO;2-M
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：3249 / +
页数：5
相关论文
共 27 条
[1]  
COULL JM, 1999, Patent No. 9922018
[2]  
Dueholm KL, 1997, NEW J CHEM, V21, P19
[3]   DETECTION OF SPECIFIC POLYMERASE CHAIN-REACTION PRODUCT BY UTILIZING THE 5'-]3' EXONUCLEASE ACTIVITY OF THERMUS-AQUATICUS DNA-POLYMERASE [J].
HOLLAND, PM ;
ABRAMSON, RD ;
WATSON, R ;
GELFAND, DH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (16) :7276-7280
[4]   Peptide nucleic acids (PNA): Synthesis, properties and potential applications [J].
Hyrup, B ;
Nielsen, PE .
BIOORGANIC & MEDICINAL CHEMISTRY, 1996, 4 (01) :5-23
[5]  
Li J. J., 2000, ANGEW CHEM, V112, P1091
[6]   Homogeneous detection of specific DNA sequences by fluorescence quenching and energy transfer [J].
Morrison, LE .
JOURNAL OF FLUORESCENCE, 1999, 9 (03) :187-196
[7]   Structural and biological properties of peptide nucleic acid (PNA) [J].
Nielsen, PE .
PURE AND APPLIED CHEMISTRY, 1998, 70 (01) :105-110
[8]   SEQUENCE-SELECTIVE RECOGNITION OF DNA BY STRAND DISPLACEMENT WITH A THYMINE-SUBSTITUTED POLYAMIDE [J].
NIELSEN, PE ;
EGHOLM, M ;
BERG, RH ;
BUCHARDT, O .
SCIENCE, 1991, 254 (5037) :1497-1500
[9]   Peptide nucleic acid (PNA). A DNA mimic with a pseudopeptide backbone [J].
Nielsen, PE ;
Haaima, G .
CHEMICAL SOCIETY REVIEWS, 1997, 26 (02) :73-78
[10]  
Niemeyer C.M., 1999, ANGEW CHEM, V111, P3039
123