The effect of thyroid functions on contrast-induced nephropathy in patients undergoing coronary angiography and percutaneous coronary intervention

Objective: To investigate the effects of thyroidism on the development of contrast-induced nephropathy in patients undergoing coronary angiography and percutaneous coronary intervention. Methods: The prospective, observational study was conducted at Trakya University Faculty of Medicine, Edirne, Turkey, from October 1, 2016, to October 1, 2017, and comprised patients with hypothyroidism, hyperthyroidism and euthyroid patients. Thyroid and renal functions were evaluated from blood samples taken before the procedure. The definition of contrast-induced nephropathy included absolute (0.5 mg/dL) or relative increase (25%) in serum creatinine 48-72 h after exposure to a contrast agent compared with baseline serum creatinine values. SPSS 10 was used for data analysis. Results: Of the 162 patients, 58(35.8%) had hypothyroidism, 47(29%) hyperthyroidism and 57(35.2%) euthyroid. Contrast-induced nephropathy was significantly higher in hypothyroid and hyperthyroid subjects compared to euthyroid group (p<0.001 each). Univariate analysis showed contrast volume, procedure, albumin value, hypothyroidism and hyperthyroidism to be independent predictors of contrast-induced nephropathy (p<0.05 each), but multivariate analysis only showed hypothyroidism and the hyperthyroidism as the independent predictors (p<0.01 each). Conclusion: Contrast-induced nephropathy rate was increased in patients with malfunctioning thyroid, Hypothyroidism and hyperthyroidism were found to be independent predictors of contrast-induced nephropathy.