ESR as a monitoring method of the interactions between TEMPO-functionalized magnetic nanoparticles and yeast cells

被引:17
|
作者
Krzyminiewski, Ryszard [1 ]
Dobosz, Bernadeta [1 ]
Schroeder, Grzegorz [2 ]
Kurczewska, Joanna [2 ]
机构
[1] Adam Mickiewicz Univ, Fac Phys, Med Phys Div, Uniwersytetu Poznanskiego 2, PL-61614 Poznan, Poland
[2] Adam Mickiewicz Univ, Fac Chem, Uniwersytetu Poznanskiego 8, PL-61614 Poznan, Poland
关键词
IRON-OXIDE NANOPARTICLES; DOXORUBICIN; DYNAMICS; EPR; RADIOTHERAPY; CHEMISTRY; RESONANCE; RADICALS; FIELD;
D O I
10.1038/s41598-019-55335-z
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Potential application of magnetic nanoparticles as drug carriers in medical treatment requires prior determination of their effects on cells. In this work different spin labels and magnetic nanoparticles functionalized with spin labels as well as their interaction with yeast cells were investigated using electron spin resonance (ESR) method. ESR was demonstrated to be a suitable method for monitoring of magnetic core and attached spin labels. Particular emphasis was placed on characterization of endocytosis and redox processes running inside the cell, resulting in recombination of spin labels. Such data could only be obtained at reduced temperature of ESR measurements.
引用
收藏
页数:11
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