Olfactory disturbances in ageing with and without dementia: towards new diagnostic tools

被引:14
作者
Gros, A. [1 ,3 ,5 ,6 ]
Manera, V. [3 ]
De March, C. A. [4 ,8 ]
Guevara, N. [2 ]
Konig, A. [3 ]
Friedman, L. [9 ,10 ]
Robert, P. [1 ,3 ]
Golebiowski, J. [4 ,7 ]
David, R. [1 ,3 ]
机构
[1] Nice Univ Hosp, Inst Univ Face & Cou, Ressource & Res Memory Ctr, Nice, France
[2] Nice Univ Hosp, Inst Univ Face & Cou, Dept Ear Nose Throat Surg, Nice, France
[3] Univ Nice Sophia Antipolis, CoBTek Cognit Behav Technol, Nice, France
[4] Univ Nice Sophia Antipolis, Inst Chem, Nice, France
[5] Univ Burgundy, Dijon Stroke Registry, EA4184, Univ Hosp Dijon, Dijon, France
[6] Univ Burgundy, Dijon Stroke Registry, EA4184, Med Sch Dijon, Dijon, France
[7] DGIST, Dept Brain & Cognit Sci, Daegu Metropolitan City, South Korea
[8] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC USA
[9] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA
[10] Stanford Univ, Stanford Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
关键词
Smell; Aging; Dementia; Alzheimer Disease; Early Diagnosis; MILD COGNITIVE IMPAIRMENT; SMELL IDENTIFICATION TEST; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; ODOR IDENTIFICATION; CHRONIC RHINOSINUSITIS; MAJOR DEPRESSION; MULTIGENE FAMILY; APOLIPOPROTEIN-E; DYSFUNCTION;
D O I
10.1017/S0022215117000858
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Background: Olfactory disorders increase with age and often affect elderly people who have pre-dementia or dementia. Despite the frequent occurrence of olfactory changes at the early stages of neurodegenerative disorders such as Alzheimer's disease, olfactory disorders are rarely assessed in daily clinical practice, mainly due to a lack of standardised assessment tools. The aims of this review were to (1) summarise the existing literature on olfactory disorders in ageing populations and patients with neurodegenerative disorders; (2) present the strengths and weaknesses of current olfactory disorder assessment tools; and (3) discuss the benefits of developing specific olfactory tests for neurodegenerative diseases. Methods: A systematic review was performed of literature published between 2000 and 2015 addressing olfactory disorders in elderly people with or without Alzheimer's disease or other related disorders to identify the main tools currently used for olfactory disorder assessment. Results: Olfactory disorder assessment is a promising method for improving both the early and differential diagnosis of Alzheimer's disease. However, the current lack of consensus on which tests should be used does not permit the consistent integration of olfactory disorder assessment into clinical settings. Conclusion: Otolaryngologists are encouraged to use olfactory tests in older adults to help predict the development of neurodegenerative diseases. Olfactory tests should be specifically adapted to assess olfactory disorders in Alzheimer's disease patients.
引用
收藏
页码:572 / 579
页数:8
相关论文
共 80 条
[1]   Dietary intake and olfactory function in patients with newly diagnosed Parkinson's disease: a case-control study [J].
Aden, Emma ;
Carlsson, Maine ;
Poortvliet, Eric ;
Stenlund, Hans ;
Linder, Jan ;
Edstrom, Mona ;
Forsgren, Lars ;
Haglin, Lena .
NUTRITIONAL NEUROSCIENCE, 2011, 14 (01) :25-31
[2]   Predictors of Olfactory Dysfunction in Rhinosinusitis Using the Brief Smell Identification Test [J].
Alt, Jeremiah A. ;
Mace, Jess C. ;
Buniel, Maria C. F. ;
Soler, Zachary M. ;
Smith, Timothy L. .
LARYNGOSCOPE, 2014, 124 (07) :E259-E266
[3]   Olfaction and Aging: A Mini-Review [J].
Attems, Johannes ;
Walker, Lauren ;
Jellinger, Kurt A. .
GERONTOLOGY, 2015, 61 (06) :485-490
[4]   Very early changes in olfactory functioning due to Alzheimer's disease and the role of Apolipoprotein E in olfaction [J].
Bacon, AW ;
Bondi, MW ;
Salmon, DP ;
Murphy, C .
OLFACTION AND TASTE XII: AN INTERNATIONAL SYMPOSIUM, 1998, 855 :723-731
[5]   Olfactory identification deficits and associated response inhibition in obsessive-compulsive disorder: On the scent of the orbitofronto-striatal model [J].
Bersani, Giuseppe ;
Quartini, Adele ;
Ratti, Flavia ;
Pagliuca, Giulio ;
Gallo, Andrea .
PSYCHIATRY RESEARCH, 2013, 210 (01) :208-214
[6]   Visual dysfunction in patients with Parkinson's disease and essential tremor [J].
Bradvica, Ivanka Stenc ;
Bradvica, Mario ;
Matic, Suzana ;
Reisz-Majic, Patricia .
NEUROLOGICAL SCIENCES, 2015, 36 (02) :257-262
[7]   A NOVEL MULTIGENE FAMILY MAY ENCODE ODORANT RECEPTORS - A MOLECULAR-BASIS FOR ODOR RECOGNITION [J].
BUCK, L ;
AXEL, R .
CELL, 1991, 65 (01) :175-187
[8]   Assessment of the Olfactory Function in Italian Patients with Type 3 von Willebrand Disease Caused by a Homozygous 253 Kb Deletion Involving VWF and TMEM16B/ANO2 [J].
Cenedese, Valentina ;
Mezzavilla, Massimo ;
Morgan, Anna ;
Marino, Renato ;
Ettorre, Cosimo Pietro ;
Margaglione, Maurizio ;
Gasparini, Paolo ;
Menini, Anna .
PLOS ONE, 2015, 10 (01)
[9]   Influences of age and sex on a microencapsulated odor memory test [J].
Choudhury, ES ;
Moberg, P ;
Doty, RL .
CHEMICAL SENSES, 2003, 28 (09) :799-805
[10]   Olfaction and apathy in Parkinson's disease [J].
Cramer, Christina K. ;
Friedman, Joseph H. ;
Amick, Melissa M. .
PARKINSONISM & RELATED DISORDERS, 2010, 16 (02) :124-126