Positron emission tomography imaging of small animals in anticancer drug development

被引：16
|
作者：
Aboagye, Eric O. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Ctr Clin Sci, Mol Therapy & PET Oncol Res Grp, London W12 0NN, England
来源：
MOLECULAR IMAGING AND BIOLOGY | 2005年 / 7卷 / 01期
基金：
英国医学研究理事会; 英国惠康基金;
关键词：
small animal imaging; PET; anticancer; drug development;
D O I：
10.1007/s11307-005-0886-2
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Positron emission tomography (PET) imaging of small animals enables researchers to bridge the gap between in vitro science and in vivo human studies. The imaging paradigm can be established and refined in animals before implementation in humans and image data related to ex vivo assays of biological activity. Small animal PET (saPET) imaging enables assessment of baseline focal pathophysiology, pharmacokinetics, biological target modulation and the efficacy of novel drugs. The potential and challenge of this technology as applied to anticancer drug development is discussed here.
引用
收藏
页码：53 / 58
页数：6
相关论文
共 50 条
  • [31] Spatiotemporal in vivo imaging of peptide receptors with high resolution in small animals using positron emission tomography (microPET)
    Johnstroem, P.
    Fryer, T. D.
    Richards, H. K.
    Barret, O.
    Clark, J. C.
    Pickard, J. D.
    Davenport, A. P.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2004, 18 : 74 - 74
  • [32] Imaging metabotropic glutamate receptor system: Application of positron emission tomography technology in drug development
    Xu, Youwen
    Li, Zizhong
    MEDICINAL RESEARCH REVIEWS, 2019, 39 (05) : 1892 - 1922
  • [33] Quantification in positron emission tomography for research in pharmacology and drug development
    Cunningham, VJ
    Gunn, RN
    Matthews, JC
    NUCLEAR MEDICINE COMMUNICATIONS, 2004, 25 (07) : 643 - 646
  • [34] Applications of Positron Emission Tomography in Neuropsychiatric Pharmaceutical Drug Development
    Miller, Jeffrey M.
    Kumar, Dileep
    Mann, J. John
    Parsey, Ramin V.
    CURRENT RADIOPHARMACEUTICALS, 2008, 1 (01) : 12 - 16
  • [35] Fundamentals of positron emission tomography and applications in preclinical drug development
    Cherry, SR
    JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 41 (05): : 482 - 491
  • [36] Can positron emission tomography facilitate paediatric drug development?
    Zimmer, Luc
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2008, 22 (06) : 595 - 598
  • [37] Utility of positron emission tomography for drug development for heart failure
    Papadimitriou, Lampros
    Smith-Jones, PeterM.
    Sarwar, Chaudhry M. S.
    Marti, Catherine N.
    Yaddanapudi, Kavitha
    Skopicki, Hal A.
    Gheorghiade, Mihai
    Parsey, Ramin
    Butler, Javed
    AMERICAN HEART JOURNAL, 2016, 175 : 142 - 152
  • [38] Using positron emission tomography to facilitate CNS drug development
    Lee, Chi-Ming
    Farde, Lars
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2006, 27 (06) : 310 - 316
  • [39] IMAGING HUMAN BRAIN-DEVELOPMENT WITH POSITRON EMISSION TOMOGRAPHY
    CHUGANI, HT
    PHELPS, ME
    JOURNAL OF NUCLEAR MEDICINE, 1991, 32 (01) : 23 - 26
  • [40] Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents
    Mathis, Chester A.
    Mason, N. Scott
    Lopresti, Brian J.
    Klunk, William E.
    SEMINARS IN NUCLEAR MEDICINE, 2012, 42 (06) : 423 - 432
12345