Severe agitation in severe early-onset Alzheimer's disease resolves with ECT

被引：16

作者：

Aksay, Suna Su ^{[1
]}

Hausner, Lucrezia ^{[1
]}

Froelich, Lutz ^{[1
]}

Sartorius, Alexander ^{[1
]}

机构：

[1] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Psychiat & Psychotherapy, D-68159 Mannheim, Germany

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2014年 / 10卷

关键词：

dementia; electroconvulsive therapy; cognition; emotional distress; disinhibition; ELECTROCONVULSIVE-THERAPY; ELDERLY-PATIENTS; SEIZURE QUALITY; DEMENTIA; EFFICACY; DEPRESSION; SAFETY; SYMPTOMS; DISTURBANCES; METAANALYSIS;

D O I：

10.2147/NDT.S71008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dementia-related behavioral disturbances are mostly treated with antipsychotics; however, the observed beneficial effects are modest and the risk of serious adverse effects high. We report the case of a 57-year-old woman with severe early-onset Alzheimer's disease and severe agitation, whom we treated with electroconvulsive therapy (ECT). A significant clinical improvement was achieved over eight ECT sessions, which were tolerated well without cognitive worsening, and lasted approximately 3 months. Our case demonstrates the safe and effective use of ECT in pharmacotherapy-resistant severe agitation in Alzheimer's disease. The risk-benefit profile of ECT for dementia-related agitation should be further investigated in clinical trials.

引用

页码：2147 / 2151

页数：5

共 38 条

[1]

Acharya D, 2014, INT J GERIATR PSYCHI

[2] Effects of right unilateral electroconvulsive therapy on motor cortical excitability in depressive patients [J].