Physiological Functions of Nedd4-2: Lessons from Knockout Mouse Models

被引：60
作者：
Manning, Jantina A. [1 ,2 ]
Kumar, Sharad [1 ,2 ]
机构：
[1] Univ South Australia, Ctr Canc Biol, GPO Box 2471, Adelaide, SA 5001, Australia
[2] SA Pathol, GPO Box 2471, Adelaide, SA 5001, Australia
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2018年 / 43卷 / 08期
基金：
英国医学研究理事会;
关键词：
EPITHELIAL NA+ CHANNEL; UBIQUITIN LIGASE NEDD4-2; TIGHT JUNCTION FORMATION; CELL-SURFACE EXPRESSION; GATED SODIUM-CHANNELS; HECT DOMAIN; LIDDLE SYNDROME; WW DOMAIN; PY MOTIF; PROTEIN;
D O I：
10.1016/j.tibs.2018.06.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein modification by ubiquitination plays a key evolutionarily conserved role in regulating membrane proteins. Nedd4-2, a ubiquitin ligase, targets membrane proteins such as ion channels and transporters for ubiquitination. This Nedd4-2-mediated ubiquitination provides a crucial step in controlling the membrane availability of these proteins, thus affecting their signaling and physiological outcomes. In one well-studied example, Nedd4-2 fine-tunes the physiological function of the epithelial sodium channel (ENaC), thus modulating Na+ reabsorption by epithelia to maintain whole-body Na+ homeostasis. This review summarizes the key signaling pathways regulated by Nedd4-2 and the possible implications of such regulation in various pathologies.
引用
收藏
页码：635 / 647
页数：13
相关论文
共 108 条
[41]   HYPERTENSION CAUSED BY A TRUNCATED EPITHELIAL SODIUM-CHANNEL GAMMA-SUBUNIT - GENETIC-HETEROGENEITY OF LIDDLE SYNDROME [J].
HANSSON, JH ;
NELSONWILLIAMS, C ;
SUZUKI, H ;
SCHILD, L ;
SHIMKETS, R ;
LU, Y ;
CANESSA, C ;
IWASAKI, T ;
ROSSIER, B ;
LIFTON, RP .
NATURE GENETICS, 1995, 11 (01) :76-82
[42]   Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases [J].
Hanukoglu, Israel ;
Hanukoglu, Aaron .
GENE, 2016, 579 (02) :95-132
[43]   Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions [J].
Harvey, KF ;
Kumar, S .
TRENDS IN CELL BIOLOGY, 1999, 9 (05) :166-169
[44]   Regulation of amino acid transporter ATA2 by ubiquitin ligase Nedd4-2 [J].
Hatanaka, Takahiro ;
Hatanaka, Yasue ;
Setou, Mitsutoshi .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (47) :35922-35930
[45]   The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels [J].
He, Yaowu ;
Hryciw, Deanne H. ;
Carroll, Melanie L. ;
Myers, Stephen A. ;
Whitbread, Astrid K. ;
Kumar, Sharad ;
Poronnik, Philip ;
Hooper, John D. .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (35) :24000-24010
[46]  
Henshall T K. S, 2018, ENCY SIGNALING MOL, P3401
[47]   Deletion of &ITNedd4-2&IT results in progressive kidney disease in mice [J].
Henshall, Tanya L. ;
Manning, Jantina A. ;
Alfassy, Omri S. ;
Goel, Pranay ;
Boase, Natasha A. ;
Kawabe, Hiroshi ;
Kumar, Sharad .
CELL DEATH AND DIFFERENTIATION, 2017, 24 (12) :2150-2160
[48]   Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons [J].
Howitt, Jason ;
Putz, Ulrich ;
Lackovic, Jenny ;
Doan, Anh ;
Dorstyn, Loretta ;
Cheng, Hong ;
Yang, Baoli ;
Tailoi Chan-Ling ;
Silke, John ;
Kumar, Sharad ;
Tan, Seong-Seng .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (36) :15489-15494
[49]   Nedd4-2 functionally interacts with ClC-5 - Involvement in constitutive albumin endocytosis in proximal tubule cells [J].
Hryciw, DH ;
Ekberg, J ;
Lee, A ;
Lensink, IL ;
Kumar, S ;
Guggino, WB ;
Cook, DI ;
Pollock, CA ;
Poronnik, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (53) :54996-55007
[50]   Maturation of the epithelial Na+ channel involves proteolytic processing of the α- and γ-subunits [J].
Hughey, RP ;
Mueller, GM ;
Bruns, JB ;
Kinlough, CL ;
Poland, PA ;
Harkleroad, KL ;
Carattino, MD ;
Kleyman, TR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (39) :37073-37082
12345678910